Iranian Biomedical Journal
مجله بیومدیکال ایران
IBJ
Basic Sciences
http://ibj.pasteur.ac.ir
1
admin
1028-852X
2008-823X
-
10.61186/ibj
-
8888
-
en
jalali
1379
12
1
gregorian
2001
3
1
5
2
online
1
fulltext
en
A New Mathematical Model to Investigate Drug Treatment on the Overall Process of Wound Healing
A New Mathematical Model to Investigate Drug Treatment on the Overall Process of Wound Healing
مقاله کامل
Full Length/Original Article
The absence of a universally accepted mathematical model for assessment of the effectiveness of drugs in the process of wound healing is one of the problems the health professionals have been faced. In this study, an “empirical” mathematical model is presented to evaluate its reliability from an experimental viewpoint and from a comparative aspect with previous models used to study wound healing, namely the log and square root models. The excisional wounds inflicted were based on suggestion of Cross et al., 1995, using a variety of drugs. The drugs influence the wound healing process such as indomethacin, mepyramine, dexamethasone, acetylsalicylic acid and prednisolone. The proposed model is based on a quadratic equation having two constants: and. The -/ ratio and the area-under the curve (AUC) are suggested as being valuable and reliable quantitative values. Also, having more precision in predicting and for expressing the effectiveness of drugs on the wound healing process than the two previous models.
Mathematical model, Wound healing, Quadratic equation, Wound surface area, Area-under the curve
61
67
http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-341&slc_lang=en&sid=1
Mohammad H.
Pipelzadeh
محمد حسن
پیپل زاده
100319475328460057856
100319475328460057856
Yes
Abolghasem
Jouyban
ابوالقاسم
جویبان
100319475328460057857
100319475328460057857
No
Ali
Khodadadi
علی
خدادادی
100319475328460057858
100319475328460057858
No
Ian L.
Naylor
Ian L.
Naylor
100319475328460057859
100319475328460057859
No