Iranian Biomedical Journal
مجله بیومدیکال ایران
IBJ
Basic Sciences
http://ibj.pasteur.ac.ir
1
admin
1028-852X
2008-823X
-
10.61186/ibj
-
8888
-
en
jalali
1379
12
1
gregorian
2001
3
1
5
2
online
1
fulltext
en
Hormone-Induced Variation of PhosphatidatePhosphohydrolase Activity in Various Tissues of Pregnant Rats
Hormone-Induced Variation of Phosphatidate Phosphohydrolase Activity in Various Tissues of Pregnant Rats
مقاله کوتاه
Short Communication
<p>Variations in phosphatidate phosphohydrolase (PAP) activity and triacylglycerol concentration were measured in pregnant and hormone-treated non-pregnant female rats. PAP activity in adipose tissue was elevated by 61% during pregnancy. The increase in the enzyme activity was paralleled with a rise in serum triacylglycerol concentration (44%). Estradiol injecting into non-pregnant rats increased PAP activity of both adipose tissue (19.8%) and the liver (26%). Progesterone also elevated the enzyme activities of adipose tissue and liver by 10% and 55%, respectively. Both hormones increased serum triacylglycerol concentration (20-29%). The data demonstrated that hypertriglyceridemia observed during pregnancy was mediated through the hormonal effects on PAP activity, a key enzyme in glycerolipid metabolism.</p>
Phosphohydrolase, Hyperlipidemia, Pregnancy
103
106
http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-339&slc_lang=en&sid=1
Bahram
Haghighi
بهرام
حقیقی
100319475328460057877
100319475328460057877
Yes
Mahboobeh
Farsadi
محبوبه
فرسادی
100319475328460057878
100319475328460057878
No