en اثر الئوروپین بر فعالیت میلوپراکسیداز بافتی در مدل تجربی ضایعه تروماتیک نخاع Related Fields Related Fields مقاله کوتاه Short Communication <p><font size="2"><span color:="" font-size:="" mso-ansi-language:="" mso-bidi-language:="" mso-fareast-font-family:="" mso-fareast-language:="" new="" style="FONT-FAMILY: " times=""><strong><font size="2">Background:</font></strong></span><span color:="" font-size:="" mso-ansi-language:="" mso-bidi-language:="" mso-fareast-font-family:="" mso-fareast-language:="" new="" style="FONT-FAMILY: " times=""><font size="2"> Neutrophil infiltration plays an important role in inflammatory reactions following spinal cord injury (SCI) and these cells cause substantial secondary tissue damage. The purpose of this study was to determine the<b>&nbsp;</b>effect of oleuropein (OE) on myeloperoxidase (MPO) activity as an index of neutrophil infiltration. <b>Methods:</b> Rats were randomly divided into four groups of 7 rats</font> <font size="2">each as follows: sham-operated group, trauma group, and OE treatment groups (20 mg/kg, i.p., immediately and 1 hour after SCI).<span dir="rtl"><font face="Times New Roman">&nbsp;</font></span>Spinal cord samples were taken 24 hours after injury and studied for determination of MPO<span dir="rtl"><font face="Times New Roman">&nbsp;</font></span>activity. <b>Results:</b> The results showed that MPO activity was significantly decreased in OE-treated rats. <b>Conclusion:</b> On the basis of our findings, we propose that OE may be effective in protecting rat spinal cord from secondary damage by modulating of neutrophil infiltration.</font></span></font></p> Oleuropein (OE), Neutrophil infiltration, Myeloperoxidase 164 167 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-325&slc_lang=en&sid=1 Ali Reza Khalatbary علیرضا خلعتبری khalat90@yahoo.com Yes Hassan Ahmadvand حسن احمدوند No