other Related Fields Related Fields کنگره Congress <div style="text-align: justify;"><span style="font-family:Times New Roman;"><span style="font-size:12pt"><span style="background:white"><span style="line-height:normal"><span style="unicode-bidi:embed"><b><span style="font-size:10.5pt"><span style="color:#222222">Introduction: </span></span></b><span style="font-size:10.5pt"><span style="color:#222222">Cardiovascular diseases remain the leading global cause of mortality, with the adult human heart exhibiting minimal regenerative capacity after myocardial infarction (MI). Metal-organic frameworks (MOFs) have emerged as highly promising multifunctional platforms in cardiac tissue engineering due to their ultra-high surface area, tunable porosity, and capabilities as scaffolds, coatings, and controlled-release carriers. This study comprehensively reviews the potential of MOFs in cardiac regeneration, with particular emphasis on their readiness for next-generation surface modification techniques.</span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="background:white"><span style="line-height:normal"><span style="unicode-bidi:embed"><b><span style="font-size:10.5pt"><span style="color:#222222">Materials and Methods: </span></span></b><span style="font-size:10.5pt"><span style="color:#222222">We conducted a systematic literature review (2010&ndash;2024) across databases such as PubMed, Scopus, and Web of Science. Keywords included &ldquo;metal-organic frameworks&rdquo;, &ldquo;MOFs&rdquo;, &ldquo;cardiac regeneration&rdquo;, &ldquo;myocardial infarction&rdquo;, and &ldquo;drug delivery&rdquo;. The review concentrated on Zr-, Zn-, and Fe-based MOFs (UiO-66, ZIF-8, MIL-series, PCN-333), their synthesis routes, surface functionalization strategies, biocompatibility assays, and preclinical cardiac models (rodent MI, zebrafish). Special attention was given to MOF systems that can undergo post-synthesis modification, including plasma-based surface activation.</span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="background:white"><span style="line-height:normal"><span style="unicode-bidi:embed"><b><span style="font-size:10.5pt"><span style="color:#222222">Results: </span></span></b><span style="font-size:10.5pt"><span style="color:#222222">MOFs demonstrated excellent cytocompatibility (>92% cardiomyocyte viability), sustained release of growth factors/miRNAs, enhanced angiogenesis, reduced fibrosis, and up to 68% infarct size reduction in rodent models. The abundant surface functional groups and thermal/chemical stability of MOFs render them ideal substrates for cold-plasma treatment, plasma polymerization, and plasma-induced grafting techniques, which have been proven to improve protein adsorption, cell adhesion, and anti-thrombogenic properties.</span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="unicode-bidi:embed"><b><span style="font-size:10.5pt"><span style="color:#222222">Conclusion: </span></span></b><span style="font-size:10.5pt"><span style="color:#222222">MOFs are a versatile, clinically translatable platform for cardiac repair. Their inherent structural advantages, combined with their readiness for plasma-mediated surface biofunctionalization, position them as next-generation materials capable of addressing proliferation, vascularization, and immunological barriers in post-MI regeneration.</span></span></span></span></span></span></div> <br> &nbsp; <table align="center" border="1" cellpadding="0" cellspacing="0"> <tbody> <tr> <td></td> <td><img alt="" height="84" src="./files/site1/images/Picture1.jpg" width="507" ></td> <td></td> </tr> </tbody> </table> Cardiac regeneration, Controlled drug delivery, Myocardial infarction, Metal-organic frameworks, Plasma surface modification 41 41 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-903&slc_lang=other&sid=1 Alireza Tehranian Yes Bahareh Farasati Far No Reza Nahavandi No