other Related Fields Related Fields دیدگاهی-مروری Perspective Review <div style="text-align: justify;"><span style="font-family:Times New Roman;"><span style="font-size:10.5pt"><span style="line-height:115%">Rabies is a fatal zoonotic disease, responsible for approximately 59,000 human deaths annually; the majority occur in developing regions of Asia and Africa. This review explores worldwide efforts to prevent and control rabies during 2016&ndash;2025, using the evolving themes of World Rabies Day (WRD) as a framework. The research objective is to assess epidemiological trends, intervention strategies, challenges, and innovations related to the World Health Organization&#39;s target of zero human rabies deaths by 2030. The findings highlight a significant reduction in global rabies occurrence, with mass vaccination campaigns for dogs achieving 70% coverage in Guinea and a 95% decrease in human cases in Latin America. However, gaps in surveillance, vaccine shortages, and poor public education persist. Low-cost intradermal prophylaxis, monoclonal antibodies, and AI-driven surveillance systems are promising approaches but remain constrained by socioeconomic inequalities and insufficient investment. Achieving &ldquo;Zero by 30&rdquo; requires stronger collaboration, equitable resource distribution, and sustained community mobilization. </span></span></span></div> One Health, Post-exposure prophylaxis, Rabies, Zoonoses 125 131 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-6347-2&slc_lang=other&sid=1 Ashkan Alamdary 0000-0001-7776-8809 No Research and Development Department, Production and Research Complex, Pasteur Institute of Iran, Karaj, Iran; Mehdi Ajorloo 0000-0002-4829-2255 No Biological Products and Blood Safety Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran Alireza Gholami 0000-0003-0706-2821 Yes Research and Development Department, Production and Research Complex, Pasteur Institute of Iran, Karaj, Iran;