en Cancer Biology Cancer Biology مقاله مروری Review Article <div style="text-align: justify;"><span style="font-family:Times New Roman;"><span style="font-size:10.5pt"><span style="line-height:115%"><span style="color:black">Effective communication between cells is a fundamental feature of multicellular organisms, occurring through direct contact or the transfer of secreted molecules. Among these mediators, extracellular vesicles (EVs) function as biological messengers that transport bioactive molecules among cells. EVs are secreted by nearly all cell types. The interaction between tumor cells and EV components has been shown to influence various cancer-related processes, including proliferation, metastasis, stemness, chemoresistance, and immune modulation. Among the bioactive cargos of EVs, non-coding RNAs (ncRNAs), particularly microRNAs (miRNAs), play a significant role in shaping the tumor microenvironment. These EV-derived ncRNAs have emerged as promising tools for non-invasive diagnosis, prognosis, and therapeutic intervention across multiple cancer types. This review summarizes the current understanding of the functional roles of EV-derived miRNAs in cancer and highlights their potential clinical applications as novel biomarkers and therapeutic targets in cancer management. </span></span></span></span></div> Extracellular vesicles, MicroRNAs, Neoplasms, Tumor microenvironment 1 15 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-6279-1&slc_lang=en&sid=1 Faezeh Maroufi faezeh.maroufi7@gmail.com 0000-0003-1368-8636 No Department of Medical Biotechnology, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran. 2. Department of Medical Biotechnology, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran. Amirali Ebrahimpour EbrahimpourA@varastegan.ac.ir 0009-0006-0741-6211 No Department of Medical Laboratory Sciences, Varastegan Institute for Medical sciences, Mashhad, Iran. Fatemeh Davami f.davami@gmail.com 0000-0002-7693-2926 Yes Department of Medical Biotechnology, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran