en Related Fields Related Fields مقاله مروری Review Article <div style="text-align: justify;"><span style="font-family:Times New Roman;"><span lang="EN" style="font-size:10.5pt"><span style="line-height:115%"><span new="" roman="" times="">The use of medicinal plants by diabetic patients dates back to ancient times. In recent years, numerous reports have been published on the efficacy and safety of many medicinal plants in the treatment of diabetes through various mechanisms. This review highlights the up-to-date proposed mechanisms of action of the most common antidiabetic herbs used in </span></span></span><span style="font-size:10.5pt"><span style="line-height:115%"><span new="" roman="" times="">Persian</span></span></span><span lang="EN" style="font-size:10.5pt"><span style="line-height:115%"><span new="" roman="" times=""> medicine, </span></span></span><span style="font-size:10.5pt"><span style="line-height:115%"><span new="" roman="" times="">comprising</span></span></span><span style="font-size:10.5pt"><span style="line-height:115%"><span new="" roman="" times=""> <i>Cinnamomum zeylanicum, Trigonella foenum-graecum, Urtica dioica, Nigella sativa, Citrullus colocynthis, Silybum marianum, Zingiber officinale, Punica granatum, Salvia officinalis, Vaccinium arctostaphylos, and Momordica charantia</i>,<i> </i>with support from clinical and experimental studies</span></span></span><span lang="EN" style="font-size:10.5pt"><span style="line-height:115%"><span new="" roman="" times="">. Clinical research has shown significant reductions in blood glucose levels and insulin resistance, as well as improvements in diabetes-related symptoms, including digestive disorders and lipid dysregulation, </span></span></span><span style="font-size:10.5pt"><span style="line-height:115%"><span new="" roman="" times="">accompanied by negligible adverse effects. Continuing to study how these plants work and how effectively they treat diabetes is important for using these natural treatments in modern medicine, offering affordable and safe options for diabetes patients. </span></span></span></span></div> Diabetes mellitus, Hypoglycemic agents, Persian medicinal plants, Traditional medicine 279 293 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-6259-1&slc_lang=en&sid=1 Hasan Fallah Huseini hiseinifallah@gmail.com 0000-0002-3192-6012 No Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran Masoud Haghighi m.haghighi@riau.ac.ir 0000-0002-5413-5248 No Iranian Fisheries Science Research Institute (IFSRI), Coldwater Fishes Research Center (CFRC), Agriculture Research, Education and Extension Organization (AREEO), Tonekabon-Iran Saeed Kianbakht kianbakht@imp.ac.ir 0000-0002-2086-248X No Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran Mojtaba Ziaee m.ziaee@tbzmed.ac.ir 0000-0002-9725-3033 Yes Medicinal Plants Research Center, Maragheh University of Medical Sciences, Maragheh, Iran.