en The Effect of Gnidilatimonoein from Daphne mucronata, on the Adhesive Property of Human Platelets مقاله کامل Full Length/Original Article <font face="times new roman,times,serif">The adhesive interaction between tumor cells and the host cells or the extracellular matrix plays a crucial role in tumor metastasis. To evaluate the mediation of cell adhesion by Daphne mucronata, an anti-cancer medicinal plant in Iranian folk medicine, the adhesion of thrombin activated human platelets to the cultured monocytes or HL-60 cells was investigated under the effect of the plant extract (0.54 mg/ml) or one of its purified components (gnidilatimonoein, 0.94 &micro;M). Treatment of the platelets with the plant extract or the active component, for various time intervals, followed by their activation by thrombin resulted in 80-90% reduction in the number of monocytes with more than 10 attached platelets. Similarly, under almost all identical conditions, the adhesion of the activated platelets to HL-60 cells was decreased by 90%. The adhesion of thrombin activated human platelets to the plant treated HL-60 cells was also reduced significantly (by 95%). These data clearly indicate that Daphne mucronata is capable of mediating tumor metastasis through effecting cell adhesion properties of the cells </font> Cell adhesion, D. mucronata, Cancer, Metastasis 143 147 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-234&slc_lang=en&sid=1 Manijeh Mianabadi منیژه میان آبادی No Razieh Yazdanparast راضیه یزدان پرست Yazdan@ibb.ut.ac.ir Yes