en Related Fields Related Fields مقاله کوتاه Short Communication <div><span style="font-family:Times New Roman;"><span style="font-size:11pt"><span style="line-height:normal"><b><span style="font-size:10.5pt"><span style="color:black">Background</span></span></b><span style="font-size:10.5pt"><span style="color:black">: The role of <i>Toxascaris leonina</i> in visceral larva migrans is controversial. This study aimed to investigate the migratory behavior of <i>T. leonina</i> larvae across different organs in mice. </span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><b><span style="font-size:10.5pt"><span style="color:black">Methods</span></span></b><span style="font-size:10.5pt"><span style="color:black">: Six-week-old Swiss albino mice (n = 26) were randomly allocated into six experimental groups and one control group.&nbsp;Each mouse in the experimental groups was orally inoculated with 1,000 embryonated <i>T. leonina</i> eggs. The animals were euthanized at 2, 5, 10, 15, 20 and 30 dpi (</span></span><span style="font-size:9.0pt">days post-infection)</span><span style="font-size:10.5pt"><span style="color:black">. Tissue samples were examined for larval presence and associated pathological changes using digestive and histopathological methods. The squash method was used for brain tissue analysis. </span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><b><span style="font-size:10.5pt"><span style="color:black">Results</span></span></b><span style="font-size:10.5pt"><span style="color:black">: <i>T. leonina</i> larvae were recovered from the small intestinal wall, lungs, liver, and striated muscles. No larvae were detected in the kidneys, heart, spleen, and brain using digestive or squash methods. Histological examination revealed granulomatous reactions, inflammatory cell accumulation, and larval presence in the isolated tissues. Larval concentration in the striated muscles increased over time, demonstrating the potential of Swiss albino mice to serve as paratenic hosts in toxocariasis. </span></span></span></span><br> <b><span style="font-size:10.5pt"><span style="line-height:115%"><span style="color:black">Conclusion</span></span></span></b><span style="font-size:10.5pt"><span style="line-height:115%"><span style="color:black">:&nbsp;Our study exhibits that Swiss albino mice are susceptible to <i>T. leonina</i> infection, with larvae localizing primarily in the small intestinal wall, liver, lungs, and striated muscles. </span></span></span></span></div> Larva migrans, Toxocariasis, Tropism 167 172 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-6145-1&slc_lang=en&sid=1 Mohammad Sardari sardari.m@gmail.com 0000-0002-7410-6946 No Department of Medical Parasitology and Mycology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran Alireza Nourian a.nouri0852@gmail.com 0000-0002-3567-8677 No Department of Pathobiology, Faculty of Veterinary Science, Bu-Ali Sina University, Hamedan, Iran Farzad Parsa farzad.parsa.5@gmail.com 0000-0001-7702-4252 No Department of Medical Laboratory Sciences, Borujerd Branch, Islamic Azad University, Borujerd, Iran Salman Zafari salman.zafari1376@gmail.com 0000-0003-2523-7111 No Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Science, Tehran, Iran Heshmatollah Taherkhani hesh.taher45@gmail.com 0000-0002-1978-7961 No Department of Medical Laboratory Sciences, Faculty of Paramedical Sciences, Islamic Azad University, Tehran, Iran Amirhossein Maghsood maghsood.a1981@gmail.com 0000-0001-7396-9371 No Department of Medical Parasitology and Mycology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran Mohammad Matini mtini.m122@gmail.com 0000-0002-1098-6382 No Department of Medical Parasitology and Mycology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran Seyed Mousa Motevali Haghi seyedmousamotavallihaghi@gmail.com 0000-0003-2974-5746 No Department of Medical Parasitology and Mycology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran Mohammad Fallah mohfall1950@gmail.com 0000-0003-1759-7387 Yes Department of Medical Parasitology and Mycology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran