Iranian Biomedical Journal
مجله بیومدیکال ایران
IBJ
Basic Sciences
http://ibj.pasteur.ac.ir
1
admin
1028-852X
2008-823X
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10.61882/ibj
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8888
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en
jalali
1404
4
1
gregorian
2025
7
1
29
4
online
1
fulltext
en
Dietary Conjugated Linoleic Acid Isomers Modify the Fatty Acid Composition of Liver and Adipose Tissues
Related Fields
Related Fields
مقاله کامل
Full Length/Original Article
<div style="text-align: justify;"><span style="font-family:Times New Roman;"><span style="font-size:11pt"><span style="line-height:normal"><b><span style="font-size:10.0pt">Background:</span></b><span style="font-size:10.0pt"> Conjugated linoleic acids (CLA) are a group of isomers derived from linoleic acid, naturally present in beef, lamb, and dairy products. CLA has been reported to exert therapeutic effects on cancer, obesity, and diabetes. This study evaluated the effects of a mixture containing equal proportions of CLA isomers (c9,t11 and t10,c12) on insulin resistance (IR) and their incorporation into the plasma membranes of adipocytes and hepatocytes in SHRs.</span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><b><span style="font-size:10.0pt">Methods:</span></b><span style="font-size:10.0pt"> For eight weeks, one group of hypertensive rats received sunflower oil supplemented with CLA isomers, while the control group received only vegetable oil. Serum parameters were measured, and the fatty acid composition of plasma membranes was analyzed using gas chromatography.</span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><b><span style="font-size:10.0pt">Results:</span></b><span style="font-size:10.0pt"> Rats treated with CLA isomers showed a reduction in body weight (BW), IR, and hypertension. Additionally, there was a significant incorporation of CLA into the plasma membranes of adipocytes and hepatocytes. In contrast, the control rats displayed higher levels of n-6 </span><span style="font-size:9.0pt">polyunsaturated fatty acid</span><span style="font-size:10.0pt"> and </span><span lang="PT-BR" style="font-size:9.0pt">arachidonic acid (</span><span style="font-size:10.0pt">AA) in their membranes, which promote the synthesis of eicosanoids and hypertensive prostaglandins. These findings were further supported by data mining analysis, which linked the results to the expression levels of genes encoding enzymes involved in the synthesis of PGE2, D2, and F2α from AA.</span></span></span><br>
<b><span style="font-size:10.0pt"><span style="line-height:115%">Conclusion:</span></span></b><span style="font-size:10.0pt"><span style="line-height:115%"> The mixture of CLA isomers reduced BW, IR, and </span></span><span style="font-size:9.0pt"><span style="line-height:115%">hypertension </span></span><span style="font-size:10.0pt"><span style="line-height:115%">in SHRs. These effects were associated with the incorporation of c9,t11 and t10,c12 isomers into the plasma membranes of adipocytes and hepatocytes.</span></span></span></div>
Adipocytes, Conjugated linoleic acid, Hepatocytes, Hypertension, Insulin resistance
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227
http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-6141-1&slc_lang=en&sid=1
Guillermo
Hernández Díaz
jedi_vs_sith@hotmail.com