other <div style="text-align: justify;"><span style="font-family:Times New Roman;"><span style="font-size:14px;"><strong><span style="color:#0e101a">Introduction:</span></strong><span style="color:#0e101a"> Multiple sclerosis (MS) is a chronic and progressive disease of the central nervous system characterized by chronic inflammation, myelin degradation of nerve cells by the immune system, and the formation of plaques in the nervous system. Fatigue is one of the significant issues for patients with MS, but usually, it gets neglected. This study aimed to determine the effect of hydroalcoholic extract of flaxseed and Nigella sativa herbal plants on the fatigue status of MS patients. </span><br> <strong><span style="color:#0e101a">Methods and Materials:</span></strong><span style="color:#0e101a"> In this clinical trial study, relevant questionnaires were completed to select the patients who meet the study criteria. Inclusion criteria required a diagnosis of RRMS, an EDSS score of less than 4, age 18 or older, and informed consent. Exclusion criteria included inability to access health information, recent disease relapse, substance abuse, smoking, alcohol use, recent vitamin D supplements, pregnancy, specific medication use, and dissatisfaction with participation. After the initial assessment, 50 patients were ultimately included in the study. These participants were divided into two groups: one group receiving hydroalcoholic extracts of flaxseed and Nigella sativa herbal plants (25 patients) and the other group receiving the placebo (25 patients). Following the intervention period, patients who did not follow up 3 months after receiving the intervention were excluded from the analysis. This led to a final inclusion of 36 patients, with 17 patients from the intervention group and 19 from the control group. Data were analyzed using SPSS 22, employing descriptive statistics and analytical methods such as t-test, Mann-Whitney U-test, and Chi-square. </span><br> <b><span style="color:#0e101a">Results:</span></b><span style="color:#0e101a"> The results of the study showed that there was no significant difference in physical function (EDSS before:1.5[2.8] vs. 1[1], <i>p</i> = 0.08 and EDSS after: 1.5[2.9] vs. 1[2], <i>p</i> = 0.22) and cognitive function (SDMT before: 50[38] vs 47[35], <i>p</i> = 0.98 and SDMT after:60[39] vs 51[25], <i>p</i> = 0.42) between the two groups before and after the treatment period, indicating the ineffectiveness of the supplement in improving the fatigue status and overall health of the patients. The only difference between the study groups was the overall fatigue status of the patients (90[40] vs 60[80], <i>p</i> = 0.03), which was also observed before the intervention (90[35] vs 65[70], <i>p</i> = 0.03). The study groups had no significant difference in pain, stress, anxiety, sleep problems, nutrition problems, and walking difficulties (<i>p</i> = 0.05). </span><br> <b><span style="line-height:115%"><span style="color:#0e101a">Conclusion and Discussion:</span></span></b><span style="line-height:115%"><span style="color:#0e101a"> The results of this study showed that a 3-month consumption of hydroalcoholic extract of flaxseed and Nigella sativa herbal plants did not significantly improve the fatigue status of MS patients.</span></span><br> <br> <img alt="" src="./files/site1/images/888.jpg" style="width: 1000px; height: 36px;" ></span></span></div> Fatigue, Multiple sclerosis, Nigella sativa 463 463 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-4696-483&slc_lang=other&sid=1 Zahra Abdi No Amirreza Naseri No Reza Mosaddeghi Heris No Hanie Karimi No Anahita Najafi No Mir Sobhan Mousavi No Mahnaz Talebi Yes Sarvin Sanaie No Wolfgang Marx No Sanaz Hamedyazdan No Mostafa Araj Khodaei No