other <div style="text-align: justify;"><span style="font-family:Times New Roman;"><span style="font-size:14px;"><span style="unicode-bidi:embed"><span style="line-height:115%"><b><span style="line-height:115%"><span style="color:black">Introduction: </span></span></b><span style="line-height:115%"><span style="color:black">Inflammatory bowel disease is a chronic condition characterized by chronic inflammation of the digestive tract. It has two primary subtypes: ulcerative colitis (UC) and Crohn&#39;s disease (CD). While both conditions involve tissue damage, their initial mechanisms and immune system dysregulation differ. Tumor necrosis factor-alpha (TNF-&alpha;) plays a crucial role in both UC and CD, contributing to the pathogenesis of these diseases. This study aimed to investigate the therapeutic potential of the extract from the <i>Ailanthus altissima</i> plant (tree of heaven) in treating UC. </span></span></span></span><br> <span style="unicode-bidi:embed"><span style="line-height:115%"><b><span style="line-height:115%"><span style="color:black">Methods and Materials: </span></span></b><span style="line-height:115%"><span style="color:black">The extract was evaluated for its ferric-reducing capacity, total phenol, and total flavonoid content. Thirty male rats were randomly divided into six groups: a control group, a regular group, a positive control group receiving mesalazine (300 mg/kg), and three treatment groups receiving the <i>A. altissima</i> extract at doses of 50, 100, and 200 mg/kg for seven days. All animals, except the standard group, received an infusion of 4% acetic acid into the large intestine. After 48 hours, the animals were euthanized. </span></span></span></span><br> <span style="unicode-bidi:embed"><span style="line-height:115%"><b><span style="line-height:115%"><span style="color:black">Results: </span></span></b><span style="line-height:115%"><span style="color:black">The results showed that the acetic acid infusion caused severe acute inflammation in the colonic tissue, significantly improved by the <i>A. altissima</i> extract at all examined doses in microscopic and macroscopic aspects. TNF-&alpha; levels were significantly lower in the mesalazine and 200 mg/kg <i>A. altissima</i> extract groups than in the control group. </span></span></span></span><br> <b><span style="line-height:115%"><span style="color:black">Conclusion and Discussion: </span></span></b><span style="line-height:115%"><span style="color:black">The study concluded that the extract of <i>A. altissima</i> demonstrated valuable therapeutic effects in treating UC, particularly at 200 mg/kg. The reduction in TNF-&alpha; levels, histological data, and macroscopic observations supported the efficacy of the extract. Future studies are recommended to further elucidate the mechanisms of action of this plant extract in treating UC.</span></span><br> <br> <img alt="" src="./files/site1/images/888.jpg" style="width: 1000px; height: 36px;" ></span></span></div> Acetic acid, Ailanthus, Colitis, Inflammatory bowel diseases 371 371 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-4696-393&slc_lang=other&sid=1 Sajjad Ghobakhlou Yes Mohammad Hosein Farzai No