Iranian Biomedical Journal
مجله بیومدیکال ایران
IBJ
Basic Sciences
http://ibj.pasteur.ac.ir
1
admin
1028-852X
2008-823X
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10.61186/ibj
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8888
-
en
jalali
1384
4
1
gregorian
2005
7
1
9
3
online
1
fulltext
en
اثر تخفیفدهنده وابسته به اندوتلیوم شنبلیله بر پاسخگویی انقباضی-عروقی موشهای دیابتی
Endothelium-Dependent Attenuating Effect of Trigonella foenum-graecum on the Contractile Vascular Reactivity of Diabetic Rats
مقاله کامل
Full Length/Original Article
<font face="times new roman,times,serif">The present study was undertaken to determine whether two-month treatment of streptozotocin (STZ)-diabetic rats with aqueous leaf extract of Trigonella foenum-graecum (TFG 200 mg/kg i.p.) could improve thoracic aortic responsiveness and to evaluate its endothelium dependency. For this purpose, vascular responses to KCl and noradrenaline (NA) were measured. Diabetic state significantly increased contractile responses to KCl and NA in aortic rings in both endothelium-intact and -denuded rings. Extract-treated diabetic rats showed a significant lower maximal contractile response to KCl only in endothelium-intact rings as compared to diabetic rings. It is concluded that intraperitoneal administration of aqueous leaf extract of TFG for two months could improve some functional indices of the vascular system in diabetic state and the integrity of the endothelium is essential for its beneficial effects </font>
Trigonella foenum-graecum (TFG), Diabetes mellitus, Streptozotocin, aorta,
129
133
http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-203&slc_lang=en&sid=1
Mohammad Reza
Vaez Mahdavi
محمدرضا
واعظ مهدوی
100319475328460057411
100319475328460057411
No
Mehrdad
Roghani
مهرداد
روغنی
mehjour@yahoo.com
100319475328460057412
100319475328460057412
Yes
Tourandokht
Baluchnejadmojarad
توراندخت
بلوچ نژاد
100319475328460057413
100319475328460057413
No
Farshad
Roghani Dehkordi
فرشاد
روغنی دهکردی
100319475328460057414
100319475328460057414
No