other <div style="text-align: justify;"><span style="font-family:Times New Roman;"><span style="font-size:14px;"><span style="unicode-bidi:embed"><span style="line-height:115%"><b><span style="line-height:115%">Introduction: </span></b><span style="line-height:115%">Breast cancer is the most common malignancy among women. Artificial intelligence </span></span></span></span></span><span style="font-size:12pt"><span style="unicode-bidi:embed"><span style="line-height:115%"><span aptos="" style="font-family:"><span style="font-size:10.0pt"><span style="line-height:115%"><span calibri="" style="font-family:"><st1:citation w:st="on"><span style="font-family:Times New Roman;"><span style="font-size:14px;">(AI)</span></span></st1:citation></span></span></span></span></span></span></span><span style="font-family:Times New Roman;"><span style="font-size:14px;"><span style="unicode-bidi:embed"><span style="line-height:115%"><span style="line-height:115%"> offers a promising and powerful aid in <span style="background:white">designing and applying</span> anti-cancer vaccines. Breast cancer is an interesting target for designing AI-based vaccines. The present review aims to summarize the state of <span style="background:white">the art </span>and explore the perspective of AI-based methods in <span style="background:white">the designation</span> and application of breast cancer vaccines in Iran.</span></span></span><br> <span style="unicode-bidi:embed"><span style="line-height:115%"><b><span style="line-height:115%">Search Strategy: </span></b><span style="line-height:115%">This review performed a comprehensive search in English and Persian databases from January 2020 to March 2024. We searched the keywords &ldquo;vaccine,&rdquo; &ldquo;artificial intelligence,&rdquo; &ldquo;AI,&rdquo; &ldquo;cancer,&rdquo; &ldquo;malignancy,&rdquo; and &ldquo;breast cancer&rdquo; and their synonyms in research databases, including PubMed, Web of Science, Science Direct, Google Scholar<span style="background:white">, and </span>Magiran. After primary and secondary screenings, related articles will be included in the study.</span></span></span><br> <span style="unicode-bidi:embed"><span style="line-height:115%"><b><span style="line-height:115%">Results: </span></b><span style="line-height:115%">A total of 10300 articles with related keywords were searched, and 15 articles finally met the inclusion criteria and entered the study. Our review emphasized the revolutionizing role of AI in developing various anti-cancer vaccines. Although studies regarding the development of AI-based vaccines against breast cancer are limited in Iran, our findings indicate that computational techniques, most importantly AI, could rapidly design shared neoantigen T cell epitopes advancing and developing the field of off-the-shelf cancer vaccines and hold the promise of significantly benefiting patients.</span></span></span><br> <b><span style="line-height:115%">Conclusion and Discussion: </span></b><span style="line-height:115%">AI is a potential tool for the designation and application of anti-cancer vaccines. Although research in breast cancer is scarce, it is a potential target for designing vaccines using AI-based methods. Future studies should prioritize the development of AI-based methods for developing effective breast cancer vaccines.</span></span></span></div> <br> <span style="font-family:Times New Roman;"><img alt="" src="./files/site1/images/888.jpg" style="width: 1000px; height: 36px;" ></span> Artificial intelligence, Breast cancer, Cancer, Vaccine 81 81 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-4696-85&slc_lang=other&sid=1 Saghi Eslamzadeh No Keivan Sahebi No Armin Fereidouni Yes