Iranian Biomedical Journal
مجله بیومدیکال ایران
IBJ
Basic Sciences
http://ibj.pasteur.ac.ir
1
admin
1028-852X
2008-823X
-
10.61186/ibj
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8888
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en
jalali
1389
8
1
gregorian
2010
11
1
14
3
online
1
fulltext
en
Eucalyptus globulus (Eucalyptus) Treatment of Candidiasis in Normal and Diabetic Rats
Eucalyptus globulus (Eucalyptus) Treatment of Candidiasis in Normal and Diabetic Rats
Related Fields
Related Fields
مقاله کامل
Full Length/Original Article
Background: The leaves of Eucalyptus globulus (eucalyptus) are used for treatment of diabetes mellitus in traditional medicine. The aim of this study was to evaluate the effects of eucalyptus in treatment of established systemic infection with Candida albicans in normal and streptozotocin-induced diabetic rats. Methods: Sixty normoglycemic male Wistar rats, weighing 200-250 g, were selected and randomly divided into six groups (n= 10): normal control, control + C. albicans, control + eucalyptus + C. albicans, diabetic control, diabetic + C. albicans, diabetic + eucalyptus + C. albicans. Diabetes was induced after a single intraperitoneal injection of streptozotocin (60 mg/kg body weight) and eucalyptus was added to the diet (62.5 g/kg) and drinking water (2.5 g/L) of treated animals for 4 weeks. The concerned groups were inoculated with C. albicans 15 days after diabetes induction. At the end of one month experiment, fasted rats were killed by cervical decapitation. Blood was collected from neck vein for estimation of glucose. C. albicans concentrations were estimated in liver and kidneys using serial dilution culture of tissue homogenates. Results: Eucalyptus administration significantly improved the hyperglycemia, polydipsia, polyphagia, and it also compensated weight loss of diabetic rats (P<0.05). Moreover, eucalyptus caused a significant reduction in C. albicans concentration in liver and kidney homogenates (P<0.01). Conclusion: The results revealed that eucalyptus improves Candidia infection in normal and diabetic rats that in some ways validates the traditional use of this plant in treatment of diabetic patients.
Diabetes mellitus, Eucalyptus globulus, Candida albicans
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http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-180&slc_lang=en&sid=1
Mohammad
Bokaeian
محمد
بکائیان
bokaeian.m@gmail.com
100319475328460056765
100319475328460056765
Yes
Alireza
Nakhaee
علیرضا
نخعی
100319475328460056766
100319475328460056766
No
Bita
Moodi
بیتا
مودی
100319475328460056767
100319475328460056767
No
Hossein Ali
Khazaei
حسینعلی
خزاعی
100319475328460056768
100319475328460056768
No