Iranian Biomedical Journal
مجله بیومدیکال ایران
IBJ
Basic Sciences
http://ibj.pasteur.ac.ir
1
admin
1028-852X
2008-823X
-
10.61186/ibj
-
8888
-
en
jalali
1389
8
1
gregorian
2010
11
1
14
3
online
1
fulltext
en
Expression of ROR1 in Patients with Renal Cancer-A Potential Diagnostic Marker
Expression of ROR1 in Patients with Renal Cancer-A Potential Diagnostic Marker
Related Fields
Related Fields
مقاله کامل
Full Length/Original Article
Background: The ectopic expression of receptor tyrosine kinase Ror1 has been reported in patients with hematological malignancies such as chronic lymphocytic leukemia and acute lymphoblastic leukemia. Here we report, for the first time, expression of ROR1 gene in both tumor tissues and peripheral blood mononuclear cells (PBMC) from patients with renal cancer (RC). Methods: In the current study, the expression of ROR1 gene was semi-quantitatively measured in PBMC and tumor tissues from 16 RC patients as well as PBMC from 22 healthy individuals relative to the expression of the housekeeping gene phosphoglucomutase 1 by RT-PCR. Results: Our results showed that ROR1 was expressed at gene level in 81.3% of renal tumor tissues (13 out of 16) whereas it was expressed in 94% of PBMC from RC patients (15 out of 16). A weak expression of ROR1 was observed in PBMC of 4 out of 22 healthy individual. A significant expression of ROR1 was observed in PBMC from RC patients when compared to that in PBMC from normal healthy individuals (P<0.001). The expression of ROR1 in PBMC may reflect a shedding of tumor cells into blood stream. Conclusion: We conclude that detection of a high level of ROR1 expression in blood cells might assist in early detection of renal malignancies, providing taking into consideration the clinical symptoms of the disease.
ROR1, Ectopic expression, Renal cancer
77
82
http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-173&slc_lang=en&sid=1
Hodjattallah
Rabbani
حجت اله
ربانی
100319475328460056730
100319475328460056730
No
Mahyar
Ostadkarampour
مهیار
استاد کرم پور
100319475328460056731
100319475328460056731
No
Amir Hossein
Danesh Manesh
امیر حسین
دانش منش
100319475328460056732
100319475328460056732
No
Abbas
Basiri
عباس
بصیری
100319475328460056733
100319475328460056733
No
Mahmood
Jeddi-Tehrani
محمود
جدی تهرانی
100319475328460056734
100319475328460056734
No
Flora
Forouzesh
فلورا
فروزش
f_foruzesh@yahoo.com
100319475328460056735
100319475328460056735
Yes