Iranian Biomedical Journal
مجله بیومدیکال ایران
IBJ
Basic Sciences
http://ibj.pasteur.ac.ir
1
admin
1028-852X
2008-823X
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10.61186/ibj
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8888
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en
jalali
1387
7
1
gregorian
2008
10
1
12
4
online
1
fulltext
en
Morphology and Synaptic Organization of Non-Dopaminergic Nigral Projections to the Medio Dorsal Thalamic Nucleus of the Rat, a Study by Anterograde Transport of PHA-L
Morphology and Synaptic Organization of Non-Dopaminergic Nigral Projections to the Medio Dorsal Thalamic Nucleus of the Rat, a Study by Anterograde Transport of PHA-L
Related Fields
Related Fields
مقاله کامل
Full Length/Original Article
Background: Mediodorsal (MD) thalamic nucleus, which is considered to take place between extra pyramidal and limbic feedback circuit, receives projective fibers from ventrolateral neurons of reticular part of substantia nigra (SNr). In order to better understand the influence and chemical reaction of these fibers upon MD nucleus, the morphology and synaptology of them were examined in the present study. Methods: Phaseolous vulgaris-leucoagglutin (PHA-L) was injected into substantia nigra pars reticulate. After 3-4 days, the sections of SNr injection site and MD nucleus were prepared. Then, we examined organization, morphology and, synaptology of PHA-L labeled SNr fibers that go to caudal and lateral part of MD thalamic nucleus. Results: At the electron microscopic level, the SNr terminals made synapses predominantly with the medium to small dendrites and far less frequently with soma and large dendrites. These terminals were packed with polymorphic synaptic vesicles and formed symmetrical synapses furthermore, it has been already recognized that cortico straital fibers from sensory-motor cortex go to region of the SNr that give rise to the nigrothalamic fibers. Conclusion: This data suggest that upon the synaptic organization, morphology and chemical nature of GABAergic, SNr fibers may have different inhibitory influence on MD neurons regulating the thalamic output from MD to cerebral cortex in the control of limbic and extra pyramidal feedback system.
Mediodorsal (MD) nucleus, Substantial nigra, Pars reticulate, Synapse
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215
http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-9&slc_lang=en&sid=1
Parichehr
Pasbakhsh
پریچهر
پاس بخش
100319475328460056947
100319475328460056947
No
Mehdi
Mehdizadeh
مهدی
مهدی زاده
maranaoo@iums.ac.ir
100319475328460056948
100319475328460056948
Yes
Gila
Behzadi
ژیلا
بهزادی
100319475328460056949
100319475328460056949
No