Iranian Biomedical Journal

en Anti-Nociceptive Effect of Sufentanil Polymeric Dissolving Microneedle on Male Mice by Hot Plate Technique Pharmaceutical Biotechnology Pharmaceutical Biotechnology مقاله کامل Full Length/Original Article <div style="text-align: justify;">Background: Despite the widespread use of opioids to manage severe pain, its systemic administration results in side effects. Among the subcutaneous and transdermal drug delivery systems developed to deal with adverse effects, microneedles have drawn attention due to their rapid action, high drug bioavailability, and improved permeability. Sufentanil (SUF) is an effective injectable opioid for treating severe pain. In this study, we investigated the analgesic effects of SUF using dissolvable microneedles. Methods: SUF polymeric dissolvable microneedles were constructed through the mold casting method and characterized by SEM and FTIR analysis. Its mechanical strength was also investigated using a texture analyzer. Fluorescence microscopy was applied in vitro to measure the penetration depth of microneedle arrays. Irritation and microchannel closure time, drug release profile, and hemocompatibility test were conducted for the validation of microneedle efficiency. Hot plate test was also used to investigate the analgesic effect of microneedle in an animal model. Results: Local administration of SUF via dissolving microneedles had an effective analgesic impact. One hour after administration, there was no significant difference between the subcutaneous and the microneedle groups, and the mechanical properties were within acceptable limits. Conclusion: Microneedling is an effective strategy in immediate pain relief compared to the traditional methods. </div> Mice, Pain management, Sufentanil 192 205 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-5608-1&slc_lang=en&sid=1 Zeinab Pourmansouri monapm1992@gmail.com 0000-0001-8028-184X No Department of Pharmacology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran Atefeh Malekkhatabi atefekhatabi@gmail.com 0000-0001-7187-546X No Department of Pharmaceutical Biomaterials, Tehran University of Medical Sciences, Tehran, Iran Maryam Toolabi maryamtoolabi62@gmail.com 0000-0003-2886-0363 No 3. Zanjan Pharmaceutical Nanotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran Mahsa Akbari akbarimahsa235@gmail.com 0000-0003-0456-6725 No Department of Biomedical Engineering, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, the Netherlands Mohammad Ali Shahbazi m.a.shahbazi@umcg.nl 0000-0002-4860-3017 Yes Department of Biomedical Engineering, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, the Netherlands Ali Rostami* rostami@zums.ac.ir 0000-0001-6474-2052 No Department of Pharmacology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran