Iranian Biomedical Journal

en Facile Green Synthesis of Iron Oxide Nanoparticles and Their Impact on Cytotoxicity, Antioxidative Properties and Bactericidal Activity Cancer Biology Cancer Biology مقاله کامل Full Length/Original Article <div style="text-align: justify;">Background: Bioreductive processes are quite potent, effective and affordable for the synthesis of green nanoparticles (NPs), as compared to the physical and chemical methods. The present study aimed to evaluate the bactericidal, antioxidative and anticancer activity of turmeric rhizome-iron oxide nanoparticles (FeONPs) derived from the turmeric rhizome (Curcuma amada) using ferric chloride as a precursor. Methods: With focusing on the manufacture of FeONPs via  green approach, we characterized the NPs using FTIR, FT-Vis, DLS, and UV-Vis spectroscopy. The produced particles were tested for antibacterial, antioxidant, and anticancer properties. The synthesized NPs were also examined using the MDA-MB-231 human epithelial breast cancer cell line and NCI-60 cancer cell lines. Results: The antioxidant activity of TR-FeONPs was concentration-dependent. The scavenging activity of TR-FeONPs was 76.09% at a concentration of 140 µg/ml. Using different concentrations of TR-FeONPs in the MTT assay against the MDA-MB-231 cell line indicated a reduction of less than 50% in cell viability at 125 µg/ml. Moreover, TR-FeONPs exhibited an effective bactericidal property. The gTR-FeONPs synthesized bioreductively were found to be effective in renal cancer, UO-31 cell line, with GI50 value of 66.64%.   Conclusion: Our study showcases a sustainable method based on green chemistry principles to produce FeONPs utilizing turmeric rhizome. We anticipate that the FeONPs produced through this biosynthesis process could serve as a promising drug delivery system in cancer treatment and as an effective antimicrobial agent against various diseases.</div> Antioxidants, Bactericidale activity, Green Synthesis, MDA-MB-231cells, Molecular docking 71 81 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-5609-1&slc_lang=en&sid=1 Sejal S. Shah sejal.shah@marwadieducation.edu.in 0000-0002-7664-4086 No Department of Bioinformatics, Faculty of Technology, Marwadi University, Rajkot, Gujarat, India Bhavika P. Turakhia No Department of Bioinformatics, Faculty of Technology, Marwadi University, Rajkot, Gujarat, India Nihar Purohit purohitnihar81@gmail.com 0000-0003-1532-9514 No Department of Life Sciences, Biotechnology Division, School of Science, GSFC University, Vadodara-391750, Gujarat, India Khushal M. Kapadiya khushal.kapadia@rku.ac.in 0000-0001-5041-1228 No School of Science, Department of Chemistry, RK University, Rajkot, Gujarat, India Chita R. Sahoo bhavika.tukeria@rku.ac.in 0000-0002-6000-7381 No Central Research Laboratory, Institute of Medical Sciences & SUM Hospital, Siksha O Anusandhan Deemed to be University, Bhubaneswar 751003, Odisha, India Akhilesh Prajapati akhilesh.prakhileshbiotech06@gmail.com 0000-0003-1532-9514 Yes Department of Life Sciences, Biotechnology Division, School of Science, GSFC University, Vadodara-391750, Gujarat, India