Iranian Biomedical Journal
مجله بیومدیکال ایران
IBJ
Basic Sciences
http://ibj.pasteur.ac.ir
1
admin
1028-852X
2008-823X
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10.61882/ibj
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8888
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en
jalali
1402
10
1
gregorian
2024
1
1
28
1
online
1
fulltext
en
Celiac Disease: A Review from Genetic to Treatment
Related Fields
Related Fields
مینی ریویو
Mini-Review
<div style="text-align: justify;"><span style="font-family:Times New Roman;"><span style="font-size:11.0pt"><span style="line-height:115%"><span new="" roman="" times=""><span style="color:black">Celiac disease (CD) is a complex disorder influenced by genetic and environmental factors. When people with a genetic predisposition to CD consume gluten, an inflammatory response is triggered in the small intestine, and this reaction can be alleviated by the elimination of gluten from the diet. The clinical manifestations of CD vary greatly from person to person and begin at a young age or in adulthood. Influence of genetic factors on CD development is evident in carriers of the DQ2 and/or DQ8 allele. HLA genotypes are associated with gut colonization by bacteria, particularly in individuals suffering from CD. In addition, beneficial gut microbes are crucial for the production of DPP-4, which plays a key role in immune function, as well as metabolic and intestinal health. Therefore, probiotics have been recommended as a complementary food supplement in CD.</span></span></span></span></span></div>
Celiac disease, Dipeptidyl peptidase 4, HLA-DQ antigens, Probiotics
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http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-5568-1&slc_lang=en&sid=1
Erfaneh
Jafari
ejafari@razi.tums.ac.ir