en Related Fields Related Fields مقاله کامل Full Length/Original Article <div style="text-align: justify;"><span style="font-family:Times New Roman;"><span style="font-size:11pt"><span style="line-height:normal"><b><span style="font-size:10.5pt"><span style="color:black">Background: </span></span></b><span style="font-size:10.5pt"><span style="color:black">Osteogenic, antioxidant and anti-inflammatory effects of Whey protein and <i>M. oleifera</i> gel prompted us to evaluate their role alone or in combination<b> </b>on osseointegration in rabbits.</span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><b><span style="font-size:10.5pt"><span style="color:black">Methods: </span></span></b><span style="font-size:10.5pt"><span style="color:black">In this study, 24 titanium implants were inserted in the femurs of six rabbits. One implant was placed without treatment, and another one was coated with a mixture of whey protein and <i>M. oleifera</i> gel for each side.&nbsp; The animals were divided into two groups of 2- and 6-week intervals<b> </b>and evaluated using histopathological and immunohistochemical techniques.</span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><b><span style="font-size:10.5pt"><span style="color:black">Results: </span></span></b><span style="font-size:10.5pt"><span style="color:black">Histological evaluation revealed a significant difference between the experimental and the control groups after two weeks in osteoblast and osteocyte counts. The experimental group had mature bone development after six weeks of implantation, while the control group had a woven bone. Immunohistochemical results showed that the experimental group, compared to the control group, exhibited early positive expression of osteoblast cells at two weeks after the experiment. Based on histopathological observations, the experimental group showed a tiny area of collagenous fiber in 6^th week after the implantation. </span></span></span></span><br> <b><span style="font-size:10.5pt"><span style="line-height:115%"><span style="color:black">Conclusion: </span></span></span></b><span style="font-size:10.5pt"><span style="line-height:115%"><span style="color:black">A mixture of whey protein and <i>M. oleifera </i>could accelerate osseointegration and healing processes.</span></span></span></span></div> Dental implants, Insulin-like growth factor I, Moringa oleifera, Osseointegration, Whey proteins 82 89 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-5561-2&slc_lang=en&sid=1 Nawar Bahjet Kamil nawar.bahjat@codental.uobaghdad.edu.iq 0000-0003-4192-0631 Yes Department of Oral Diagnosis, College of Dentistry, University of Baghdad, Baghdad, Iraq Nada M.H. AL-Ghaban 0000-0002-9969-2021 No Department of Oral Diagnosis, College of Dentistry, University of Baghdad, Baghdad, Iraq