en تظاهر HLA-G برروی سلولهای دندریتیک القاء شده توسط TGF-β1 و تکثیر سلولهای C‌D4+ T Related Fields Related Fields مقاله کامل Full Length/Original Article Background: During antigen capture and processing, mature dendritic cells (DC) express large amounts of peptide-MHC complexes and accessory molecules on their surface. DC are antigen-presenting cells that have an important role in tolerance and autoimmunity. The transforming growth factor-beta1 (TGF-&beta;1) cytokine has a regulatory role on the immune and non-immune cells. The aim of this study is to evaluate the effect of TGF-&beta;1 on the induction of human leukocyte antigen-G (HLA-G) expression on the DC which is derived from monocyte. Methods: In this study, we evaluated the effect of TGF-&beta;1 in induction HLA-G expression on the monocyte-derived DC by flowcytometry and then CD4+ T cell proliferative responses in the presence of DC-treated TGF-&beta;1 was studied. Results: The results of this study showed that DC bearing HLA-G down-regulated activation of CD4+ T cells and production of IL-6 and IL-17 in comparison with control (P<0.05). Conclusion: It is concluded that TGF-&beta;1 has an important regulatory role in CD4+ T cell proliferation by increasing HLA-G on DC and these cells can probably prevent unexpected immune responses in vivo. Human leukocyte antigen-G (HLA-G), Transforming growth factor-beta1 (TGF-β1), Dendritic cell (DC), IL-17 1 5 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-163&slc_lang=en&sid=1 Saeid Abediankenari سعید عابدیان کناری abedianks@razi.tums.ac.ir Yes Maryam Ghasemi مریم قاسمی No Young-June Kim Young-June Kim No