Iranian Biomedical Journal
مجله بیومدیکال ایران
IBJ
Basic Sciences
http://ibj.pasteur.ac.ir
1
admin
1028-852X
2008-823X
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10.61882/ibj
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8888
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en
jalali
1402
8
1
gregorian
2023
11
1
27
6
online
1
fulltext
en
The Role of High-Fructose Diet in Liver Function of Rodent Models: A Systematic Review of Molecular Analysis
Enzymology and Protein Chemistry
Enzymology and Protein Chemistry
مقاله مروری
Review Article
<span style="font-size:10.5pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:black">The present systematic review of animal studies on long-term fructose intake in rodents revealed a significant decrease in the activities of antioxidant enzymes due to a fructose-rich diet. The reduced activity of these enzymes led to an increase in oxidative stress, which can cause liver damage in rodents. Of eight studies analyzed, 5 (62.5%) and 1 (12.5%) used male and female rats, respectively, while 2 studies (25%) used female mice. Moreover, half of the studies used </span></span></span></span><span style="font-size:9.0pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">high-fructose corn syrup</span></span></span><span style="font-size:10.5pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:black">, but the other half employed fructose in the diet. Hence, it is essential to monitor dietary habits to ensure public health and nutrition research outcomes.</span></span></span></span>
Animal model, Fructose, Liver, Liver function tests, Oxidative stress
326
339
http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-5224-2&slc_lang=en&sid=1
Roya
Mirzaei
mirzaei.roya@gmail.com