en Tissue Engineering and Cell Biology Tissue Engineering and Cell Biology مقاله کامل Full Length/Original Article <span style="font-size:11pt"><span style="line-height:normal"><span calibri="" style="font-family:"><b><span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Background: </span></span></span></b><span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Autogenous bone grafts are the gold standard for being used as graft materials in maxillofacial surgery. However, a limited amount of these materials is available from the donor site, and there is also more need for a larger operating area and a second surgery, which frequently leads to unreliable graft incorporation, tooth ankylosis, and root resorption. Therefore, newer bone graft substitutes have been developed as alternatives, among which eggshell powder has been introduced as a bone substitute. This study aimed to evaluate the biocompatibility, resorption kinetics, and osteoproductivity of the unprocessed, </span></span></span><span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times="">carboxymethyl cellulose</span></span><span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"> (CMC)-coated, and gelatin-coated ostrich eggshell particles.</span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span calibri="" style="font-family:"><b><span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Methods: </span></span></span></b><span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Four half-thickness calvarial defects were created in each animal. At the end of the 1^st and 3^rd months, the defected sites were investigated by clinical, histological, radiological and histomorphometric</span></span></span><span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">al</span></span></span><span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"> methods.</span></span></span><span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span calibri="" style="font-family:"><b><span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">Results:</span></span></span></b><span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"> Coating the eggshell </span></span></span><span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">particles</span></span></span> <span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">with CMC and gelatin</span></span></span> <span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">facilitated </span></span></span><span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">the</span></span></span><span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">i</span></span></span><span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">r surgical </span></span></span><span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">application </span></span></span><span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times=""><span style="color:black">and contributed to new bone formation.</span></span></span><span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"> However, their newly formed bone rate at the 3^rd month was lower than those of the unprocessed eggshell particles. The CMC coating was more effective than gelatin coating in the bone modeling process.</span></span></span><span style="font-size:10.5pt"><span new="" roman="" style="font-family:" times=""><span style="color:black"></span></span></span></span></span></span><br> <b><span style="font-size:10.5pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:black"><span style="letter-spacing:-.5pt">Conclusion: </span></span></span></span></span></b><span style="font-size:10.5pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times=""><span style="color:black">Ostrich eggshell particles either in native form or coated with CMC could be used as a bone filler for supporting new bone formation and healing in treatment of osseous </span></span></span></span><span style="font-size:10.5pt"><span style="line-height:115%"><span new="" roman="" style="font-family:" times="">defects.</span></span></span> Carboxymethyl cellulose, Eggshell particles, Gelatin 366 374 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-5393-2&slc_lang=en&sid=1 İlhami Çelik icel@selcuk.edu.tr 0000-0002-3587-7609 Yes Selçuk University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Kampüs 42080, Konya, Türkiye Ercan Durmuş durerc@yahoo.com 0000-0003-4851-4230 No Selçuk University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Kampüs 42080, Konya, Türkiye Alkın Uysal alkinunsal@gmail.com 0000-0002-4849-1561 No Selçuk University, Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Kampüs 42080, Konya, Türkiye