en ارتباط پلیمرفیسم های Arg280His ،Arg194Trp و Arg399Gln در ژن XRCC1 و خطر کارسینوم تمایز یافته تیروئید در ایران Related Fields Related Fields مقاله کامل Full Length/Original Article Background: X-ray repair cross-complementing group 1 (XRCC1) gene is a DNA repair gene and its non-synonymous single nucleotide polymorphisms (SNP) may influence DNA repair capacity which has been considered as a modifying risk factor for cancer development. Methods: A case-control study was conducted to investigate impact of three frequently studied polymorphisms (Arg194Trp, Arg280His and Arg399Gln) on developing differentiated thyroid carcinoma (DTC). Results: Increased risks for DTC were shown in homozygous (odds ratio [OR]: 3.66, 95% confidence interval [CI]: 0.38-35.60) and in dominant trait (OR: 1.22, 95% CI: 1.64-2.32) of Arg194Trp genotype. Also, for Arg280His genotype, an increased risk for DTC was shown in dominant trait (OR: 1.42, 95% confidence interval [CI]: 0.76-2.68), while a mildly reduction of risk for DTC (OR: 0.77, 95% [CI]: 0.50-1.17) was estimated in dominant Gln genotype of Arg399Gln. Considering combinatory effects of Arg194Trp and Arg280His genotypes on DTC, the calculated OR and 95% CI for being heterozygous for one of Arg194Trp or Arg280His genotypes were 1.57 and 0.90-2.74, respectively. Conclusion: Genotyping of codons 194, 280 and 399 in XRCC1 gene may use in risk assessment of DTC. Endocrine related cancer, DNA repair gene, X-ray repair cross-complementing group 1 (XRCC1) gene, Differentiated thyroid carcinoma (DTC) 73 78 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-147&slc_lang=en&sid=1 Pezhman Fard-Esfahani پژمان فرد اصفهانی fard-esfahani@pasteur.ac.ir Yes Armaghan Fard-Esfahani ارمغان فرد اصفهانی No Shima Fayaz شیما فیاض No Bahareh Ghanbarzadeh بهاره قنبرزاده No Parinaz Saidi پریناز سعیدی No Reyhaneh Mohabati ریحانه محبتی No Seyed Kazem Bidoki سید کاظم بیدکی No Mina Majdi مینا مجدی No