Iranian Biomedical Journal

en Alteration in Serum Levels of Tumor Necrosis Factor Alpha is associated with Histopathologic Progression of Gastric Cancer Cancer Biology Cancer Biology مقاله کوتاه Short Communication Background: The role of inflammatory cytokines, such as tumor necrosis- alpha (TNF-α) and IL-8, in gastric carcinogenesis has been investigated, but their impact remains to be further elucidated. Methods: In this study, we measured the serum concentrations of these cytokines and H. pylori serostatus in dyspeptic patients, presenting with normal mucosa (NM = 53), chronic gastritis (CG = 94), and gastric cancer (GC = 82), by ELISA. Results: Moderate levels of TNF-α were detected in the NM group (19.9 ± 19.5 pg/ml), which were nearly doubled in patients with CG (35.7 ± 28.0 pg/ml) and drastically declined in GC patients (1.8 ± 5.9 pg/ml). The serum levels of IL-8, however, were not statistically different amongst these three groups. Conclusion: TNF-α serum concentration seemed to undergo up- and downregulation, when moving from NM to CG and from CG to GC, respectively. If confirmed in a prospective study, this cytokine can behave as a serum indicator of gastric inflammation and malignant transformation. Inflammation, Interleukin-8, cytokines, Tumor necrosis factor-alpha 66 71 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-5173-1&slc_lang=en&sid=1 Mehdi Alikhani alikhanim81@gmail.com 0000-0002-8808-9577 No HPGC Research Group, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran Maryam Esmaeili m_esmaily2007@yahoo.com 0000-0002-6203-4332 No HPGC Research Group, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran Mohammad Tashakoripour No Gastroenterology Department, Amiralam Hospital, Tehran University of Medical Sciences, Tehran, Iran Mohammad Ali Mohagheghi 0000-0003-4153-0991 No Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran Mahmoud Eshagh Hosseini No Gastroenterology Department, Amiralam Hospital, Tehran University of Medical Sciences, Tehran, Iran Eliette Touati eliette.touati@pasteur.fr 0000-0002-3450-1773 No Institut Pasteur, Unit of Helicobacter Pathogenesis, CNRS UMR2001, 25-28 Rue du Dr Roux, 75724 Paris Cedex 15, France Massoud Vosough masvos@yahoo.com 0000-0002-5396-4714 No Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran Marjan Mohammadi marjan.mohammadi2010@gmail.com 0000-0003-4970-3455 Yes HPGC Research Group, Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran