Iranian Biomedical Journal

en Seroprevalence of Herpes Simplex Viruses Types 1 and 2 in a Population, Age 15-35 Years, of Mashhad City Molecular Microbiology Molecular Microbiology مقاله کوتاه Short Communication <div style="text-align: justify;">Background: Considering the high prevalence and clinical importance of herpes simplex virus (HSV) infection worldwide, we aimed to evaluate the seroprevalence of HSV-1 and HSV-2 in a population aged between 15 and 35 years in Mashhad, Iran. Methods: This cross-sectional study was conducted on 916 cases composed of 288 (31.4%) men and 628 (68.6%) women. Using ELISA method, the presence of IgM and IgG antibodies against HSV-1 and HSV-2 was assessed. Results: Among the population studied, 681 (74.3%) cases were positive for anti-HSV antibodies, while 235 (25.7%) cases were negative. Moreover, no IgMs were found and all positive subjects had IgG antibodies. Age (p < 0.001), occupation (p < 0.001), education (p = 0.006), smoking (p = 0.029), and BMI (p = 0.004) demonstrated a significant association with HSV-1 and HSV-2 infection. Conclusion: Our study indicates a high seroprevalence of HSV infection; however, there was no cases positive for IgM antibodies, suggesting the high prevalence of latent infection.  </div> Herpes Simplex Virus Type 1, Herpes Simplex Virus Type 2, Iran, Seroepidemiology 152 157 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-5126-1&slc_lang=en&sid=1 Ahmad Taherpoor ahmadtaherpour1375@gmail.com 0000-0002-7398-750X No Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Arastoo Vojdani VejdaniA4001@mums.ac.ir 0000-0001-7898-6605 No Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Seyed Mohamad Ali Hashemi dr.alihashemi73@gmail.com 0000-0001-6731-9110 No Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Arian Amali arianamali77@yahoo.com 0000-0001-6350-2751 No Student Research Committee, Paramedical Department, Mashhad Medical Sciences Branch, Islamic Azad University, Mashhad, Iran Mohammad Reza Mardani MardaniMR4001@mums.ac.ir 0000-0002-6810-2180 No Department of Microbiology and Virology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Majid Ghayour Mobarhan ghayourm@mums.ac.ir 0000-0003-2852-7632 No International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Habibollah Esmaily esmailyh@mums.ac.ir 0000-0003-4139-546X No Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran MohammadTaghi Shakeri Shakerimt@mums.ac.ir 0000-0002-8287-9594 No Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Mansoureh Bakhshi tahmine.bakhshi@gmail.com 0000-0002-1877-8588 No Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Mojtaba Meshkat m.meshkat@sbmu.ac.ir 0000-0003-0507-3295 No Department of Community Medicine, Faculty of Medicine, Mashhad Medical Sciences, Islamic Azad University, Mashhad, Iran Amin Hooshyar Chechaklou amin.hooshyar@ymail.com 0000-0002-2158-8670 No Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Samaneh Abolbashari AbolbashariS1@mums.ac.ir 0000-0002-4854-5822 Yes Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Aida Gholoubi gholoubiad@mums.ac.ir 0000-0001-6399-1612 No Metabolic Syndrome Research Center and Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Zahra Meshkat meshkatz@mums.ac.ir 0000-0002-4032-7599 No Antimicrobial Resistance Research Center, Mashhad University of Medical Sciences, Mashhad, Iran