en Molecular Immunology & Vaccines Molecular Immunology & Vaccines مقاله مروری Review Article <div style="text-align: justify;"><span style="font-family:Times New Roman;"><span style="font-size:10.5pt"><span style="line-height:107%"><span new="" roman="" times="">Immunometabolism is an emerging field in tumor immunotherapy. Understanding the metabolic competition for access to the limited nutrients between tumor cells and immune cells can reveal the complexity of the tumor microenvironment and help develop new therapeutic approaches for cancer. R</span></span></span><span style="font-size:10.5pt"><span style="line-height:107%"><span new="" roman="" times=""><span style="color:#0e101a">ecent studies have focused on modifying the function of immune cells by manipulating their metabolic pathways. Besides, identifying metabolic events, which affect the function of immune cells leads to new therapeutic opportunities for treatment of inflammatory diseases and immune-related conditions. According to the literature, metabolic pathway such as glycolysis, </span></span></span></span><span lang="EN-GB" style="font-size:10.5pt"><span style="line-height:107%"><span new="" roman="" times=""><span style="color:black">tricarboxylic acid</span></span></span></span><span style="font-size:10.5pt"><span style="line-height:107%"><span new="" roman="" times=""><span style="color:#0e101a"> cycle, and fatty acid metabolism,</span></span></span></span> <span style="font-size:10.5pt"><span style="line-height:107%"><span new="" roman="" times=""><span style="color:#0e101a">significantly influence the survival, proliferation, activation, and function of immune cells and thus regulate immune responses. In this paper, we reviewed the role of metabolic processes and major signaling pathways involving in T-cell regulation and T-cell responses against tumor cells. Moreover, we summarized the new therapeutics suggested to enhance anti-tumor activity of T cells through manipulating metabolic pathways.</span></span></span></span></span></div> Cancer, Metabolic pathways,Metabolism, T-cell 1 14 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-5091-1&slc_lang=en&sid=1 Jahangir Abdesheikhi j.abdeshaikhi@gmail.com 0000-0002-8371-6359 No Department of Immunology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran Farnaz Sedghy fsedghy@gmail.com 0000-0001-7436-9116 Yes Department of Immunology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran Merat Mahmoodi merat.mahmoodi@yahoo.com 0000-0001-5773-3051 No Department of Immunology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran Hossein Fallah hf59ma@gmail.com 0000-0001-6196-0775 No Department of Biochemistry, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran Mahdi Ranjkesh ranjkeshroudan@gmail.com 0000-0002-9201-8341 No Department of Immunology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran