Iranian Biomedical Journal
مجله بیومدیکال ایران
IBJ
Basic Sciences
http://ibj.pasteur.ac.ir
1
admin
1028-852X
2008-823X
-
10.61186/ibj
-
8888
-
en
jalali
1401
12
1
gregorian
2023
3
1
27
2
online
1
fulltext
en
Synthesis and Characterization of Thymol-Loaded Niosomal Film for the Prevention of Implant-Related Infection
Tissue Engineering and Cell Biology
Tissue Engineering and Cell Biology
مقاله کامل
Full Length/Original Article
<p style="text-align: justify;"><span style="font-family:Times New Roman;"><span style="font-size:11pt"><span style="line-height:normal"><b><span style="font-size:10.5pt"><span style="color:black">Background</span></span></b><span style="font-size:10.5pt"><span style="color:black">: Infection is one of the significant challenges in medical implant-related surgeries. Despite systemic antibiotic therapies, bacterial growth after implantation may cause implant failure. Nowadays, unlike the systemic therapy, local controlled release of antibiotic agents is considered an effective approach for the prevention of implant-related infections. The present study aimed to develop a niosomal nanocarrier incorporated into fibroin films for local and continuous delivery of thymol, a natural plant-derived antimicrobial agent for preventing infections caused by implant-related.</span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><b><span style="font-size:10.5pt"><span style="color:black">Methods</span></span></b><span style="font-size:10.5pt"><span style="color:black">: Niosomes containing thymol were prepared by thin-film hydration technique. Thymol sustained release from the prepared films was assessed for 14 days. Antibacterial activities of the synthesized films were also evaluated by the agar diffusion technique against <i>Escherichia coli</i>,<i> Pseudomonas aeruginosa</i>, and<i> Staphylococcus aureus.</i></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><b><span style="font-size:10.5pt"><span style="color:black">Results</span></span></b><span style="font-size:10.5pt"><span style="color:black">: The release behavior from the niosomal thymol films showed a sustained manner, in which the amount of the released thymol reached 40% after 14 days. The films containing thymol with and without niosome showed a significant viability against L929<i> </i>fibroblast cells</span></span> <span style="font-size:10.5pt"><span style="color:black">compared to other groups after 24 and 48 h, using MTT assay. Also, samples exhibited potent antibacterial activity against Gram-negative and Gram-positive bacteria. </span></span></span></span><br>
<b><span style="font-size:10.5pt"><span style="line-height:115%"><span style="color:black">Conclusion</span></span></span></b><span style="font-size:10.5pt"><span style="line-height:115%"><span style="color:black">: The results of this study demonstrate that the niosomal thymol-loaded fibroin film is a promising candidate for the controlled release of thymol and prevention of implant-related infection.</span></span></span></span></p>
Thymol, Infections, Wound healing
117
125
http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-5004-1&slc_lang=en&sid=1
Raziyeh
Najafloo
raziyeh.najafloo@gmail.com
100319475328460064486
100319475328460064486
No
Department of Biomedical Engineering, Amirkabir University of Technology (Tehran Polytechnic), Tehran159163-4311, Iran
Rana
Imani
r.imani@aut.ac.ir
100319475328460064487
100319475328460064487
Yes
Department of Biomedical Engineering, Amirkabir University of Technology (Tehran Polytechnic), Tehran159163-4311, Iran
Mahla
Behyari
m_behyari73@yahoo.com
100319475328460064488
100319475328460064488
No
Department of Biomedical Engineering, Amirkabir University of Technology (Tehran Polytechnic), Tehran159163-4311, Iran
Shirin
Nour
shirin.nour94@gmail.com
100319475328460064489
100319475328460064489
No
Department of Biomedical Engineering, Amirkabir University of Technology (Tehran Polytechnic), Tehran159163-4311, Iran