Iranian Biomedical Journal

en Antitumorigenic Effect of Cannabidiol in Lung Cancer: What Do We Know So Far?–A Mini Review Cancer Biology Cancer Biology مقاله مروری Review Article Lung cancer remains a major factor contributing to morbidity and mortality worldwide. cannabidiol (CBD) and Δ9-tetrahydrocannabinol could serve as a specific treatment for lung cancer, owing to their essential role in lung cancer cell apoptosis. This review evaluated the antitumorigenic mechanisms of CBD in lung cancer cells. We searched the databases MEDLINE, clinicaltrials.gov, Cochrane Central Register of Controlled Trials, and Google Scholar using specific terms. Of 246 studies screened, nine were included and assessed using the ToxRTool. All the selected studies were conducted in vitro, and four of which also had an in vivo content. The most common cell line used in all the studies was A549; however, some studies contained other cell lines, including H460 and H358. Our findings suggested that CBD has direct antineoplastic effects on lung cancer cells through various mechanisms mediated by cannabinoid receptors or independent of these receptors. All studies were referred to an in vitro model; hence, further research in animals is required.   Cannabidiol, Cannabinoids, Lung cancer 406 413 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-4843-2&slc_lang=en&sid=1 Vasileios Issares vasilisiss@gmail.com 0000-0001-6107-9400 Yes Athens General Hospital 'Evangelismos, Athens, Greece Gerasimos panagiotis Milas jerrymilas@gmail.com 0000-0002-6794-1302 No Penteli Children’s Hospital, Athens, Greece Nicholas Zareifopoulos nizareifopoulos@gmail.com 0000-0002-2080-6744 No General Hospital of Nikaia Agios Panteleimon, Athens, Greece