Iranian Biomedical Journal

en On-Admission Anemia and Survival Rate in COVID-19 Patients Related Fields Related Fields گزارش تحقیقاتی Brief Report Background: Anemia often worsens the severity of respiratory illnesses, and few studies have so far elucidated the impact of anemia on COVID-19 infection. This study aimed to evaluate the effect of anemia at admission on the overall survival of COVID-19 patients using accelerated failure time (AFT) models. Methods: This registry-based, single-center retrospective cohort study was conducted in a university hospital in Ilam, the southwest of Iran, between March 2020 and September 2021. AFT models were applied to set the data of 2,441 COVID-19 patients. Performance of AFT models was assessed using Akaike’s information criterion (AIC) and Cox-Snell residual. On-admission anemia was defined as hemoglobin (Hb) concentration <120 g/l in men, <110 g/l in women, and <100 g/l in pregnant women. Results: The median in-hospital survival times for anemic and non-anemic patients were 27 and 31 days, respectively. Based on the AIC and Cox-Snell residual graph, the Weibull model had the lowest AIC and it was the best fitted model to the data set among AFT models. In the adjusted model, the results of the Weibull model suggested that the anemia (adjusted time ratio: 1.04; 95% CI: 1.00-1.08; p = 0.03) was the accelerated factor for progression to death in COVID-19 patients. Each unit of increase in hemoglobin in COVID-19 patients enhanced the survival rate by 4%. Conclusion: Anemia is an independent risk factor associated with the risk of mortality from COVID-19 infection. Therefore, healthcare professionals should be more sensitive to the Hb level of COVID-19 patients upon admission. Anemia, COVID-19, Risk factors, Mortality, Survival 389 397 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-4876-2&slc_lang=en&sid=1 Reza Asadzadeh dr.r_asadzadeh@yahoo.com 0000-0001-8214-9818 No School of Medicine, Ilam University of Medical sciences, Ilam, Iran Aliashraf Mozafari amozafari99@yahoo.com 0000-0002-9962-3130 No Non-Communicable Diseases Center, Ilam University of Medical Sciences, Ilam, Iran Elham Shafiei shafiei-e@medilam.ac.ir 0000-0001-5689-5235 No Non-Communicable Diseases Center, Ilam University of Medical Sciences, Ilam, Iran Mohammadreza Kaffashian M_r_kaffashian@yahoo.com 0000-0001-5340-690X No Non-Communicable Diseases Center, Ilam University of Medical Sciences, Ilam, Iran Iraj Ahmadi Ahmadiiraj96@gmail.com 0000-0001-9065-3088 No Non-Communicable Diseases Center, Ilam University of Medical Sciences, Ilam, Iran Mohammadzaman Darvish zaman.nafise71dt@yahoo.com 0000-0001-6467-0327 No Non-Communicable Diseases Center, Ilam University of Medical Sciences, Ilam, Iran Saiyad Bastaminejad bastaminejad-s@medilam.ac.ir 0000-0001-6722-6432 Yes Non-Communicable Diseases Center, Ilam University of Medical Sciences, Ilam, Iran