Iranian Biomedical Journal
مجله بیومدیکال ایران
IBJ
Basic Sciences
http://ibj.pasteur.ac.ir
1
admin
1028-852X
2008-823X
-
10.61186/ibj
-
8888
-
en
jalali
1385
4
1
gregorian
2006
7
1
10
3
online
1
fulltext
en
کاهش استرس اکسیداتیو ایجاد شده توسط آلومینیوم توسط ملوکسیکام در مغز رت
Reduction in Aluminum Induced Oxidative Stress by Meloxicam in Rat Brain
مقاله کامل
Full Length/Original Article
<font face="times new roman,times,serif" size="2"><strong>Background:</strong> Non-steroidal anti-inflammatory drugs (NSAID) have been associated with antioxidant property and have been shown to improve the circulating antioxidant status on daily dosing in different inflammatory conditions. The present study was conducted to investigate the antioxidant role of meloxicam in aluminum induced oxidative stress in rat brain. <strong>Methods:</strong> In the in vivo experiments, Sprague-Dawley rats where randomized into 4 groups receiving daily treatment for 4 weeks: 1) double distilled water i.p., 2) 4.2 mg/kg aluminum i.p. 3) meloxicam (5.0 mg/kg, i.m.) 4) 5.0 mg/kg, meloxicam i.m. + 4.2 mg/kg aluminum i.p. brain homogenates from the above animals were assayed for lipid peroxidation levels as well as superoxide dismutase activity. In the in vitro experiments, brain homogenates from Sprague-Dawley rats were treated with either, aluminum, meloxicam or their combinations and were then assayed as per the in vivo samples. <strong>Results:</strong> In vivo data showed elevated lipid peroxidation levels in brain homogenate in aluminium-treated group as compared to aluminium + meloxicam treatment which showed a significant decrease in the malonaldehyde levels. Similar results were observed in the in vitro experiments when brain homogenates were treated with either, aluminum, meloxicam or their combinations. Furthermore, no change was observed in superoxide dismutase activity in any treatment group as compared to the control in either experiment. <strong>Conclusion:</strong> These results indicate that NSAID can be used in Alzheimer management. Iran. Biomed. J. 10 (3): 151-155, 2006</font>
Superoxide dismutase (SOD), Lipid peroxidation (LPO), Meloxicam, Alzheimer’s disease, Aluminium
151
155
http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-134&slc_lang=en&sid=1
Manish
Nikvsarkar
Manish
Nikvsarkar
manishnivsarkar@yahoo.com
100319475328460057284
100319475328460057284
Yes
Aryamitra
Banerjee
Aryamitra
Banerjee
100319475328460057285
100319475328460057285
No
Deval
Shah
Deval
Shah
100319475328460057286
100319475328460057286
No
Jaimic
Trivedi
Jaimic
Trivedi
100319475328460057287
100319475328460057287
No
Manoj
Patel
Manoj
Patel
100319475328460057288
100319475328460057288
No
Bapu
Cherian
Bapu
Cherian
100319475328460057289
100319475328460057289
No
Harish
Padh
Harish
Padh
100319475328460057290
100319475328460057290
No