Iranian Biomedical Journal
مجله بیومدیکال ایران
IBJ
Basic Sciences
http://ibj.pasteur.ac.ir
1
admin
1028-852X
2008-823X
-
10.61882/ibj
-
8888
-
en
jalali
1400
12
1
gregorian
2022
3
1
26
2
online
1
fulltext
en
Validating MARK2 Gene Polymorphism as a Predictor of Response to Lithium Treatment in Bipolar Patients
Related Fields
Related Fields
مقاله کامل
Full Length/Original Article
<strong>Ba</strong><strong>ckground: </strong>Lithium is a therapeutic option for the treatment of the acute phase of the bipolar disorder and long-term management of this disorder. However, it is estimated that 10 to 60% of patients do not properly response to this medication.<br>
<strong>Methods: </strong>To investigate the role of <em>MARK2 </em>gene in response to lithium, we genotyped the <em>MARK2 </em>rs10792421 polymorphism in Iranian bipolar patients using amplification Refractory Mutation System-PCR.<br>
<strong>R</strong><strong>e</strong><strong>sults: </strong>Results of this study showed a significant association of this polymorphism with response to lithium. The A allele was more frequent in the responder than the non-responder group and also in the semi- responder group compared to the non-responder group in the codominant model of analysis. AA and AG genotypes were more frequent in both the responder and semi-responder groups compared to the non-responder group in dominant model of analysis.<br>
<strong>Conclusion: </strong>Based on the findings of the current study, the rs10792421 variant of <em>MARK2 </em>gene could be considered as a potential biomarker for predicting the treatment outcome of bipolar disorder type 1 in Iranian population.
Bipolar, Biomarkers, Lithium, Genotyping
110
115
http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-4348-2&slc_lang=en&sid=1
Sara Sadat
Aghabozorg Afjeh