Iranian Biomedical Journal
مجله بیومدیکال ایران
IBJ
Basic Sciences
http://ibj.pasteur.ac.ir
1
admin
1028-852X
2008-823X
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10.61882/ibj
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8888
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en
jalali
1401
4
1
gregorian
2022
7
1
26
4
online
1
fulltext
en
Carboxylated Graphene Oxide as a Nanocarrier for Drug Delivery of Quercetin as an Effective Anticancer Agent
Cancer Biology
Cancer Biology
مقاله کامل
Full Length/Original Article
<span style="font-family:Times New Roman;"><span style="font-size:11pt"><span style="line-height:normal"><span calibri=""><b><span style="font-size:10.5pt">Background:</span></b> <span style="font-size:10.5pt">Enhancing the therapeutic profile of hydrophobic drugs using the development of biocompatible drug delivery systems is an urgent need. Many types of research have been conducted on graphene derivatives owing to their unique characteristics. </span> </span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span calibri=""><b><span style="font-size:10.5pt">Methods:</span></b> <span style="font-size:10.5pt">In this survey, </span><span style="font-size:10.5pt"><span style="color:black">quercetin</span></span><span style="font-size:10.5pt"> (QUER), a natural medicine, was loaded on carboxylated </span><span style="font-size:10.5pt"><span style="background:white"><span style="color:black">graphene oxide</span></span></span><span style="font-size:10.5pt"> (GO), and cytotoxicity assay and the uptake of QUER into prostate cancer cells (PC3) were evaluated.</span><span style="font-size:10.5pt"></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:normal"><span calibri=""><b><span style="font-size:10.5pt">Results:</span></b> <span style="font-size:10.5pt">The release behavior of QUER was temperature- and pH-sensitive. Although QUER was loaded with high efficiency, the released rate was low (23.25% at pH 5.5 and 42 </span><span style="font-size:10.5pt"><span new="" roman="" times="">°</span></span><span style="font-size:10.5pt">C). The toxicity and intensity of fluorescence in the FREE QUER were higher than the loaded form.</span></span></span></span><br>
<b><span style="font-size:10.5pt"><span style="line-height:115%"><span calibri="">Conclusion:</span></span></span></b> <span style="font-size:10.5pt"><span style="line-height:115%"><span calibri="">High-capacity loading and controlled release of GO QUER can be recognized as a proper candidate in treating cancer.</span></span></span></span>
Drug delivery systems, Graphene oxide, Nanoparticle, Quercetin
324
329
http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-4295-2&slc_lang=en&sid=1
fatemeh
yaghoubi
f.yaghobi67@gmail.com