Iranian Biomedical Journal
مجله بیومدیکال ایران
IBJ
Basic Sciences
http://ibj.pasteur.ac.ir
1
admin
1028-852X
2008-823X
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10.61186/ibj
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8888
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en
jalali
1400
12
1
gregorian
2022
3
1
26
2
online
1
fulltext
en
A Historic Review of the Role of CD4+ T-Cell Subsets in Development of the Immune Responses against Cutaneous and Visceral Leishmaniases
Related Fields
Related Fields
مقاله مروری
Review Article
The heterogeneity of CD4<sup>+</sup> T cells has been investigated since the late 1970s, when their Th1 and Th2 subsets were coined. Later studies on the cutaneous form of the Leishmaniasis were focused on the experimental models of <em>Leishmania major</em> infection using the susceptible BALB/c and the resistant C57BL/6 mice. At the early 21<sup>st</sup> century, the regulatory T-cells subpopulation was introduced and its role in concomitant immunity, responsible for lifelong resistance of the host to the reinfection was proposed. Subsequent studies, mainly focused on the visceral form of the infection pointed to the role of IL-17, produced by Th17 subset of CD4<sup>+</sup> T cells that along the neutrophils were shown to have important yet equivocal functions in protection against or exacerbation of the infection. Altogether, the current knowledge indicates that the above four subsets could orchestrate the immune, the regulatory and the inflammatory responses of the host against different forms of leishmaniases.
Immunity, Leishmaniasis, T-Lymphocytes
99
109
http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1338-2&slc_lang=en&sid=1
Mohammad Hossein
Alimohmmadian
mhalimoham@gmail.com
100319475328460052594
100319475328460052594
Yes
Pasteur Institute of Iran
Soheila
Ajdary
sohary@yahoo.com
100319475328460052595
100319475328460052595
No
Pasteur Institute of Iran
Fariborz
Bahrami
f_bahrami@pasteur.ac.ir
100319475328460052596
100319475328460052596
No
Pasteur Institute of Iran