en دوره زمانی تغییرات در رفتارهای اجتنابی Y-maze در موش‌های صحرایی دیابتی نر مقاله کامل Full Length/Original Article <font face="times new roman,times,serif" size="2">Diabetes mellitus is accompanied with disturbances in learning, memory, and cognitive skills in the human society and experimental animals. Therefore, this research study was conducted to evaluate time-dependent changes in passive avoidance and Y-maze performance in male diabetic rats. For this purpose, male Wistar rats were randomly divided into control and diabetic groups. For induction of diabetes, streptozotocin (STZ) was injected i.p. at a single dose of 60 mg/kg. For evaluation of learning and memory, initial latency (IL) and step-through latency (STL) were determined at the end of 1 st , 2 nd , and 3 rd months using passive avoidance and Y-maze tasks. It was found out that mean IL exhibits a significant increase only at the end of 2 nd (p<0.05) and 3 rd (p<0.01) months. In addition, STL significantly reduced at the end of 2 nd (p<0.05) and 3 rd months (p<0.01). Regarding Y-maze task, alternation score of the diabetic rats was lower than that of the control ones at the end of 1 st (p<0.05), 2 nd (p<0.01), and 3 rd (p<0.01) months as compared to time-matched control group. To conclude, at least one month is strictly required for development of behavioral disturbances in passive avoidance and Y-maze tasks in STZ-diabetic rats. </font> Learning and memory, Cognition, Passive avoidance, Y-maze, Diabetic rat, Streptozotocin (STZ) 99 104 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-125&slc_lang=en&sid=1 Mehrdad Roghani مهرداد روغنی mehjour@yahoo.com Yes Mohammad Taghi Joghataie محمدتقی جقتایی No Mohammad Reza Jalili محمدرضا جلالی No Tourandokht Baluchnejadmojarad توراندخت بلوچ نژاد مجرد No