Iranian Biomedical Journal
مجله بیومدیکال ایران
IBJ
Basic Sciences
http://ibj.pasteur.ac.ir
1
admin
1028-852X
2008-823X
-
10.61186/ibj
-
8888
-
en
jalali
1385
1
1
gregorian
2006
4
1
10
2
online
1
fulltext
en
افتراق سوشهای غالب هلیکوباکتر پیلوری جدا شده از بیماران مبتلا به پاتولوژیهای مختلف دستگاه گوارش با استفاده از سیستمهای پروتئینی
Discrimination of Dominant H. pylori Strains Isolated from Patients with Different Gastroduodenal Pathologies by Protein Profiling
مقاله کامل
Full Length/Original Article
<font face="times new roman,times,serif" size="2">It is not clear what factors determine divergent outcomes of infections caused by H. pylori . In the present study, the protein profiles of different strains of H. pylori, isolated from three groups of patients with ulcerative disease, non-ulcerative gastritis and cancer disease, were analyzed using 1DSDS-PAGE. The patterns of different H. pylori strains were highly divergent. About 30.76% (7 bands) of the 26 observed protein bands were common in all strains isolated from 3 groups of the patients. While the similarity for the strains inside each group were 75% (15 from 20), 76.47% (13 from 17) and 78.57% (11 from 14) for cancerous, ulcerative and nonulcerative group, respectively. Some of the observed bands were significantly specific for each group. Therefore, we speculated that some H. pylori strains might be more associated with a specific disease than others, giving the clustering of some, but not all, strains within each disease group. In conclusion, this study showed that protein profile can be a characteristic in discrimination of dominant strains in different gastric clinical status. Specific and dominant proteins of different strains isolated from three groups of patients under study were candidates for further exploration for laboratory tests, which analyze disease-specific H. pylori strains, and for diagnosis of the different diseases and outcomes associated with this widespread bacterium.</font>
Helicobacter pylori, SDS-PAGE, Protein profile
85
91
http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-124&slc_lang=en&sid=1
Shohreh
Farshad
شهره
فرشاد
s_farshad@yahoo.com
100319475328460057303
100319475328460057303
Yes
Abdolvahab
Alborzi
عبدالوهاب
البرزی
100319475328460057304
100319475328460057304
No
Aziz
Japoni
عزیز
ژاپونی
100319475328460057305
100319475328460057305
No
Masoumeh
Hayati
معصومه
حیاتی
100319475328460057306
100319475328460057306
No
Mehdi
Saberfirouzi
مهدی
صابرفیروزی
100319475328460057307
100319475328460057307
No
Kamran
Bagheri Lankarani
کامران
باقری لنکرانی
100319475328460057308
100319475328460057308
No
AliReza
Taghavi
علیرضا
تقوی
100319475328460057309
100319475328460057309
No
Jalil
Nasiri
جلیل
نصیری
100319475328460057310
100319475328460057310
No
Noreddin
Rafatpour
نورالدین
رفعتپور
100319475328460057311
100319475328460057311
No