Iranian Biomedical Journal
مجله بیومدیکال ایران
IBJ
Basic Sciences
http://ibj.pasteur.ac.ir
1
admin
1028-852X
2008-823X
-
10.61186/ibj
-
8888
-
en
jalali
1401
2
1
gregorian
2022
5
1
26
3
online
1
fulltext
en
A Green Approach for the Biosynthesis of Gold Nanoparticles Using Cuminum cyminum L. Seed and Its Application for Pain Management in Rats
Pharmaceutical Biotechnology
Pharmaceutical Biotechnology
مقاله کامل
Full Length/Original Article
<span style="font-size:11px;"><span style="font-family:Tahoma;"><span style="line-height:normal"><span calibri=""><b><span style="color:black">Background:</span></b> This study investigated the antinociceptive effect of cumin and its biosynthesized <span style="background:white"><span style="color:black">gold nanoparticles</span></span> (AuNPs). </span></span><br>
<span style="line-height:normal"><span calibri=""><b>Methods:</b> Cumin extract (E) and cumin-AuNPs (GN) were prepared and administered intraperitoneally at the concentrations of 200, 500, and 1000 mg/ml to 27 male rats. <span style="color:black">Ultraviolet-visible spectroscopy and </span><strong><span calibri=""><span style="color:black"><span style="font-weight:normal">atomic force microscopy</span></span></span></strong><span style="color:black"> were applied for AuNPs synthesis confirmation. The nociceptive behavior was assessed, and IL-6 serum </span>levels were measured<span style="color:black">. </span></span></span><br>
<span style="line-height:normal"><span calibri=""><b><span style="color:black">Results</span></b><span style="color:black">: Cumin-AuNPs showed a peak absorption of 515 nm, and a size of about 40 nm. Three different concentrations of extract had no significant effect on acute and chronic nociceptive behavior. GN + E200 (46.00 ± 10.59)</span> <span style="color:black">showed a significant acute anti-nociceptive effect compared to the control (98.66 ± 4.91; <i>p </i>= 0.029) and</span> <span style="color:black">SS300 (98.33 ± 20.30; <i>p </i>= 0.029) groups. Also, GN + E500 (42.00 ± 11.84) significantly reduced acute nociceptive behavior compared to the control (98.66 ± 4.91; <i>p </i>= 0.019), SS300 (98.33 ± 20.30; <i>p </i>= 0.020), and GN + E1000 (91.00 ± 26.00; <i>p </i>= 0.040) groups. IL-6 serum levels reduced significantly in GN + E500</span> <span style="color:black">(24.65 ± 10.38; <i>p </i>= 0.002) and SS300 (33.08 ± 1.68; <i>p </i>= 0.039) compared to the controls (46.24 ± 3.02). Chronic nociceptive behavior was significantly lower in the SS300 (255.33 ± 26.30) compared to E200 (477.00 ± 47.29; <i>p </i>= 0.021), E500 (496.25 ± 46.29; <i>p </i>= 0.013), and GN + E500 (437.00 ± 118.03; <i>p </i>= 0.032) groups. </span></span></span><br>
<b><span style="line-height:107%"><span calibri=""><span style="color:black">Conclusion</span></span></span></b><span style="line-height:107%"><span calibri=""><span style="color:black">: Our findings suggest the potential effects of cumin-AuNPs on formalin-induced nociceptive behavior, which is independent of IL-6serum levels.</span></span></span></span></span>
Nociceptive Behavior, Cuminum cyminum L., Cumin-AuNPs, Interleukin-6, Pain
219
229
http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-4673-1&slc_lang=en&sid=1
Sahar
Golabi
s.golabi@abadanums.ac.ir
100319475328460058701
100319475328460058701
No
Department of Medical Physiology, School of Medicine, Abadan University of Medical Sciences, Abadan, Iran
Maryam
Adelipour
delipour-m@ajums.ac.ir
100319475328460058702
100319475328460058702
No
Department of Biochemistry, School of Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Asma
Mohammadi
a.mohammadi@abadanums.ac.ir
100319475328460058703
100319475328460058703
No
Department of Biochemistry, School of Medicine, Abadan University of Medical Sciences, Abadan, Iran
Kosar
Omidian
kosar.omidian@usask.ca
100319475328460058704
100319475328460058704
No
Department of Pharmacy and Nutrition, University of Saskatchewan, SK, Canada
Ali
Rastqar
Ali.rastqarfarajzadeh.1@ulaval.ca
100319475328460058705
100319475328460058705
No
Department of Psychiatry and Neuroscience, University of Medicine, Université Laval, Quebec, QC, Canada
Mahshid
Naghashpour
mahshidnaghashpour08@gmail.com
100319475328460058706
100319475328460058706
Yes
Department of Nutrition, School of Medicine, Abadan University of Medical Sciences, Abadan, Iran