Iranian Biomedical Journal
مجله بیومدیکال ایران
IBJ
Basic Sciences
http://ibj.pasteur.ac.ir
1
admin
1028-852X
2008-823X
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10.61882/ibj
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8888
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en
jalali
1400
8
1
gregorian
2021
11
1
25
6
online
1
fulltext
en
Serum Krebs von den Lungen-6 for Predicting the Severity of COVID-19 Lung Injury: A Systematic Review and Meta-Analysis
Related Fields
Related Fields
مقاله کامل
Full Length/Original Article
<strong>Introduction: </strong>Lung injury is common in coronavirus disease 2019 (COVID-19) patients. The severity of lung injury appears to be reflected in serum Krebs von den Lungen-6 (KL-6), a glycoprotein expressed on type II alveolar epithelium. This study aims to assess the role of serum KL-6 in reflecting the severity of lung injury in COVID-19 patients. <strong>Methods: </strong>A systematic search was conducted in Scopus, PubMed, Wiley Online Library, and ProQuest. Articles were screened based on several eligibility criteria and assessed for study quality using Newcastle-Ottawa Scale. <strong>Results: </strong>This systematic review included four studies involving a total of 151 adult COVID-19 patients. Pooled analysis revealed that serum KL-6 was significantly higher in severe patients (SMD = 1.16; 95% CI = 0.69–1.63) with moderately high pooled sensitivity (79%; 95% CI = 61–91%) and specificity (86%; 95% CI = 72–95%). <strong>Conclusion: </strong>High serum KL-6 may depict more severe lung injury in COVID-19 patients with moderately high sensitivity and specificity.
Biomarker, COVID-19, Infectious disease, Krebs von den Lungen-6, Lung injury
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389
http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-4551-1&slc_lang=en&sid=1
Andro Pramana
Witarto
andropw0298@gmail.com