en Related Fields Related Fields مقاله مروری Review Article Viruses are obligatory intracellular parasites that use cell proteins to take the control of the cell functions in order to accomplish their life cycle. Studying the viral-host interactions would increase our knowledge of the viral biology and mechanisms of pathogenesis. Studies on pathogenesis mechanisms of lyssaviruses, which are the causative agents of rabies, have revealed some important host protein partners for viral proteins, especially for most studied species, i.e. Rabies virus. In this review article, the key physical lyssavirus-host protein interactions, their contributions to rabies infection, and their exploitation are discussed to improve the knowledge about rabies pathogenesis. Host-Pathogen Interactions, Lyssavirus, Rabies 226 242 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1832-3&slc_lang=en&sid=1 Fatemeh Zandi 0000-0002-4139-5948 No Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran Fatemeh Goshadrou 0000-0001-6025-7316 No Department of Basic Sciences, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran Anna Meyfour 0000-0002-7956-9712 No Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran Behrouz Vaziri 0000-0002-0295-5922 Yes Medical Biotechnology Department, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran