en Cancer Biology Cancer Biology مقاله کامل Full Length/Original Article <strong>Background:</strong> As critical regulators, lncRNAs have attracted attention from researchers for diagnostic, prognostic, and therapeutic purposes in human carcinogenesis via interfering with mRNAs such as <em>EZH2</em>. Nevertheless, the potent roles and molecular mechanisms of these RNAs in CRC are not clearly known. <strong>Methods:</strong> In this study, the tissue expressions of lncRNA <em>MINCR</em> and <em>EZH2</em> mRNA between colorectal tumors and polyps were compared<br> with the adjacent normal tissues collected from 114 Iranian patients, using real-time PCR method. Furthermore, the correlation of the expression levels of <em>MINCR</em> and <em>EZH2</em> with other clinical parameters was evaluated.&nbsp;<strong>Results:</strong> The significant overexpression of <em>MINCR</em> and <em>EZH2</em> were observed in the CRC tissues compared to control tissues (<em>p </em>< 0.0001). This observation confirmed the association of these expression enhancements with the pathological stage of CRC patients. <strong>Conclusion:</strong> Our findings revealed that the expression of <em>MINCR</em> significantly alters during CRC development, and it&nbsp;can be identified as a potential biomarker for the detection of CRC. Colorectal cancer, EZH2, Long non-coding RNA 64 69 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-4147-1&slc_lang=en&sid=1 sajjad cheraghi rs_2064@yahoo.com 0000-0002-4104-3918 No Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran. hamid asadzadeh hamid.assadzadeh@gmail.com 0000-0002-9382-9840 Yes Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. gholam reza javadi gdjavadiroberts@yahoo.com 0000-0001-5326-9394 No Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.