en Cancer Biology Cancer Biology مقاله مروری Review Article Herein, we review the current findings of how a variety of accessory cells could participate in shaping the tumor microenvironment and supporting the mechanisms by which cancer cells undertake the epithelial-mesenchymal transition (EMT). EMT, a complex of phenotypic changes, promotes cancer cell invasion and creates resistance to chemotherapies. Among the accessory cells present in the EMT, immune cells (both native and adaptive) can reciprocally influence the tumor cells features, promote EMT and negatively regulate the anticancer immune response. In this review, we look over the role of EMT in crosstalk between tumor cells and the immune system, with specific emphasis on breast tumors. Finally, we suggest that understanding the role of immune cells in cancer progression could create new opportunities for diagnostic and therapeutic interventions in cancer combination therapy. Chemokines, Cytokines, Epithelial-mesenchymal transition, Tumor microenvironment 1 7 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-836&slc_lang=en&sid=1 Raheleh Moradpoor 0000-0003-3474-7914 No Department of Basic Sciences, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran Mona Salimi 0000-0002-3997-7009 Yes Department of Physiology and Pharmacology, Pasteur Institute of Iran, Tehran, Iran