en Cancer Biology Cancer Biology مقاله کامل Full Length/Original Article <strong>Background:</strong> Large intergenic non-coding RNA regulator of reprogramming (LINC-ROR), as a cancer-related Long non-coding RNA, has vital roles in stem cell survival, pluripotency, differentiation, and self-renewal in human embryonic stem cell. However, cancer-related molecular mech&shy;anisms, its functional roles, and clinical value of LINC-ROR in gastric cancer (GC) remain unclear. In this study, we aimed to investigate probable interplay between <em>LINC-ROR</em> with <em>SALL4 </em>stemness regulator and their role with the development of the disease. <strong>Methods:</strong> The mRNA expression profile of <em>LINC-ROR</em>&nbsp;and <em>SALL4&nbsp;</em>was assessed in tumoral and adjacent non-cancerous tissues of GC patients, using quantitative real-time PCR. <strong>Results:</strong> Significant <em>LINC-ROR</em> underexpression and <em>SALL4 </em>overexpression were observed in 55.81% and 75.58% (<em>p </em>< 0.0001) of samples, respectively. The expression of <em>LINC-ROR </em>and <em>SALL4</em> were significantly correlated with each other (<em>p </em>= 0.044). There was an association between the underexpression of <em>LINC-ROR </em>and sex, stage of tumor progression, tumor type, and location of tumor (<em>p</em> < 0.05), and <em>Helicobacter pylori </em>infection with <em>SALL4</em> expression (<em>p</em> = 0.036). There were also significant correlations between concomitant mRNA expression of <em>SALL4</em> and <em>LINC-ROR</em> in tumors located at distal noncardiac, positive for <em>H.</em> <em>pylori </em>infection, tumors with invasion into the muscle layer of the stomach, and grade II tumor (<em>p</em> < 0.05).&nbsp;<strong>Conclusion: </strong>The clinical results of the <em>SALL4-LINC-ROR</em> association propose a probable functional interaction between these markers in tumor maintenance and aggressiveness. Our study can help to understand one of the mechanisms involved in the progression of gastric cancer through the function of these regulators. LINC-ROR, SALL4, Non-coding RNA 157 168 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1906-2&slc_lang=en&sid=1 Reihaneh Alsadat Mahmoudian 0000-0002-0003-9015 No Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Maryam Lotfi Gharaie 0000-0002-7309-2239 No Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Roya Abbaszadegan 0000-0002-5546-5775 No Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Mohammad Mahdi Forghanifard 0000-0002-7691-6897 No Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran Mohammad Reza Abbaszadegan 0000-0003-4539-048X Yes Medical Genetics Research Center, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran