Iranian Biomedical Journal

en Investigation of TNF-α and IL-6 Levels in the Sera of Non-Melanoma Skin Cancer Patients Cancer Biology Cancer Biology مقاله کامل Full Length/Original Article Background: TNF-α and IL-6 are both pleiotropic cytokines playing major roles in cancer-associated cytokine networks. They have previously been investigated for their function in skin malignancies, mostly melanomas, and studies on non-melanoma skin cancer (NMSC) patients are relatively rara. In this study, we aimed to investigate the associations of serum levels of IL-6 and TNF-α with NMSCs and its clinicopathological features. Methods: This cases-control study was carried out to assess the serum levels of TNF-α and IL-6 in 70 NMSC patients, in comparison with 30 healthy individuals, by means of flow cytometric bead-based immuneoassay. Results: Serum levels of both TNF-α and IL-6 were significantly higher in NMSC patients (6.470 vs. 4.355 pg/ml; p = 0.0468, respectively), compared to healthy individuals (3.205 vs. 0.000 pg/ml; p = 0.0126, respectively). In the subgroup analysis, squamous cell carcinomas patients had higher serum levels of IL-6 compared to healthy individuals (3.445 vs. 0.000 pg/ml; p = 0.0432). No other significant differences were observed in the serum levels of these two cytokines among different clinicopathological subgroups of the patients. Conclusion: The increased levels of TNF-α and IL-6 in NMSC patients can be introduced as an epiphenomenon of a complex cancer-induced cytokine cascade. Biomarkers, Cytokines, Interleukin-6, Tumor Necrosis Factor-alpha 88 92 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-2971-3&slc_lang=en&sid=1 Mehdi Ghahartars mghahartars@sums.ac.ir 0000-0003-3218-1988 No Department of Dermatology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran Shabnam Abtahi sabtahi1@bwh.harvard.edu 0000-0003-3096-8023 No Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran Zahra Zeinali paria_zeinali@yahoo.com 0000-0002-0311-1211 No Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran Mohammad Javad Fattahi mfattahi@sums.ac.ir 0000-0002-5007-242X No Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran Abbas Ghaderi ghaderia@sums.ac.ir 0000-0003-0849-3375 Yes Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran