Iranian Biomedical Journal
مجله بیومدیکال ایران
IBJ
Basic Sciences
http://ibj.pasteur.ac.ir
1
admin
1028-852X
2008-823X
-
10.61186/ibj
-
8888
-
en
jalali
1399
6
1
gregorian
2020
9
1
24
5
online
1
fulltext
en
Deregulation of Stemness-Related Genes in Endometriotic Mesenchymal Stem Cells: Further Evidence for Self-Renewal/Differentiation Imbalance
Molecular Genetics & Genomics
Molecular Genetics & Genomics
مقاله کوتاه
Short Communication
<strong>Background:</strong> Any irregularities in self-renewal/differentiation balance in endometriotic mesenchymal stem cells (MSCs) can change their fate and function, resulting in endometriosis development. This study aimed to evaluate the expression of <em>OCT4 </em>transcripts (<em>OCT4A</em>, <em>OCT4B</em>, and <em>OCT4B1</em>), <em>SOX2</em>, and <em>NANOG</em> in endometriotic MSCs to show their aberrant expression and to support self-renewal/differentiation imbalance in these cells. <strong>Methods:</strong> MSCs were isolated from three endometriotic and three normal endometrium samples and characterized and analyzed for the expressions of <em>OCT4A</em>, <em>OCT4B</em>, <em>OCT4B1</em>, <em>SOX2</em>, and <em>NANOG</em> using the quantitative real-time PCR. <strong>Results:</strong> The expressions of <em>OCT4 transcripts </em>and <em>NANOG</em> increased significantly in endometriotic MSCs, whereas <em>SOX2</em> expression did not show any significant difference. <strong>Conclusion: </strong>Our findings provide further evidence for confirming the self-renewal/ differentiation imbalance in endometriotic MSCs, as the main underlying cause of endometriosis development. This study also paves the way for further research on endometriosis treatment by focusing on endometriotic stem cells.
Endometriosis, Mesenchymal stem cells, Transcription factors
333
339
http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-823&slc_lang=en&sid=1
Parisa
Mashayekhi
100319475328460054403
100319475328460054403
No
Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
Mehrdad
Noruzinia
100319475328460054404
100319475328460054404
Yes
Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
Sepideh
Khodaverdi
100319475328460054405
100319475328460054405
No
Endometriosis Research Center, Iran University of Medical Science, Tehran, Iran