en Related Fields Related Fields مقاله کامل Full Length/Original Article <span style="font-family:Times New Roman;"><span style="font-size:11pt"><span style="unicode-bidi:embed"><span style="line-height:107%"><span calibri=""><b><span style="font-size:10.5pt"><span style="line-height:107%">Background:</span></span></b><span style="font-size:10.5pt"><span style="line-height:107%"> Mu</span></span><span style="font-size:10.5pt"><span style="line-height:107%"><span style="color:black">ltiple sclerosis</span></span></span><span style="font-size:10.5pt"><span style="line-height:107%"><span style="color:black"> (MS) is the most prevalent neurological disability of young adults. </span></span></span><span style="font-size:10.5pt"><span style="line-height:107%"><span style="color:black">Anti-inflammatory drugs have relative effects on MS. The anti-inflammatory and antioxidative effects of <i>Zingiber officinale </i>(ginger) have been proven in some experimental and clinical investigations. The </span></span></span><span style="font-size:10.5pt"><span style="line-height:107%"><span style="color:black">aim of this study was to evaluate the effects of ginger </span></span></span><span style="font-size:10.5pt"><span style="line-height:107%"><span style="color:black">extract<b> </b>on</span></span></span><span style="font-size:10.5pt"><span style="line-height:107%"><span style="color:black"> preventing myelin degradation in a rat model of MS.</span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="unicode-bidi:embed"><span style="line-height:107%"><span calibri=""><b><span style="font-size:10.5pt"><span style="line-height:107%">Methods:</span></span></b> <span style="font-size:10.5pt"><span style="line-height:107%">Forty nine male Wistar rats were used in this study and divided into four control groups: the normal group, cuprizone-induced group, sham group (</span></span><span style="font-size:10.5pt"><span style="line-height:107%"><span style="color:black">cuprizone</span></span></span><span style="font-size:10.5pt"><span style="line-height:107%"> [CPZ] + </span></span><span style="font-size:10.5pt"><span style="line-height:107%"><span style="color:black">sodium carboxymethyl cellulose</span></span></span><span style="font-size:10.5pt"><span style="line-height:107%"> [NaCMC]), standard control group (fingolimod + cuprizone), including three experimental groups of CPZ, each receiving three different doses of ginger extract: 150, 300, and 600mg/kg /kg/day</span></span><span style="font-size:10.5pt"><span style="line-height:107%"><span style="color:black">.</span></span></span><span style="font-size:10.5pt"><span style="line-height:107%"></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="unicode-bidi:embed"><span style="line-height:107%"><span calibri=""><b><span style="font-size:10.5pt"><span style="line-height:107%">Results:</span></span></b> <span style="font-size:10.5pt"><span style="line-height:107%">Ginger extract of 600 mg/kg prevented </span></span><span style="font-size:10.5pt"><span style="line-height:107%"><span style="color:black">corpus callosum</span></span></span><span style="font-size:10.5pt"><span style="line-height:107%"> from demyelination; however, a significant difference was observed in the fingolimod group (p < 0.05). Difference in the CPZ group was quite significant (p < 0.05).</span></span><span style="font-size:10.5pt"><span style="line-height:107%"></span></span></span></span></span></span><br> <b><span style="font-size:10.5pt"><span style="line-height:107%"><span calibri="">Conclusion:</span></span></span></b> <span style="font-size:10.5pt"><span style="line-height:107%"><span calibri="">Treatment with ginger inhibited demyelination and alleviated remyelination of corpus callosum in rats. Therefore, it could serve as a therapeutic agent in the MS</span></span></span><span style="font-size:10.5pt"><span style="line-height:107%"><span calibri="">. </span></span></span></span> Corpus callosum, Demyelination, Ginger extract, Multiple sclerosis, Rat 330 339 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-3672-1&slc_lang=en&sid=1 Valiollah Moradi Esfandiari@med.mui.ac.ir No Department of Anatomical Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Ebrahim Esfandiary Esfandiari@med.mui.ac.ir 0000-0001-6436-5672 Yes Department of Anatomical Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Mustafa Ghanadian 0000-0001-6446-4734 No Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran Nazem Ghasemi 0000-0002-6729-0271 No Department of Anatomical Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Bahman Rashidi 0000-0003-1133-9571 No Department of Anatomical Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran