en Molecular Immunology & Vaccines Molecular Immunology & Vaccines مقاله مروری Review Article Crohn&#39;s disease (CD) is an inflammatory disease of the gastrointestinal tract (GIT) and can affect several parts of the digestive system. There is a relationship between impaired mucosal barrier in the GIT of inflammatory bowel disease patients and the role of bacteria such as <em>Mycobacterium avium</em> in CD. Apart from different therapeutic approaches for treating CD, development of a vaccine is a novel modality. In the present article, most available therapeutic opportunities in the last decade, especially the possibility of vaccines against CD, are reviewed. According to the search, availability of a new generation of vaccines against CD is expected specially tolerogenic <em>ex vivo</em>-derived DC-based vaccines. Regarding different locations of the challenge and the variety of clinical manifests of CD and also the type of resident antigen-presenting cells and their traffic in different parts of GIT, the results of immunotherapy with DC-based vaccines may vary case by case.&nbsp; Crohn’s disease, Inflammatory bowel diseases, Vaccines 1 14 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-795&slc_lang=en&sid=1 Mohammad Rostami-Nejad 0000-0003-2495-1831 No Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran Mohammad Hossein Yazdi 0000-0001-8567-8555 No Biotechnology Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Shekoufeh Nikfar 0000-0002-5206-6197 No Pharmaceutical Sciences Research Center (PSRC), The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran Ali Rezaie 0000-0002-0106-372X No Cedars-Sinai Medical Center, Los Angeles, CA, USA Mohammad Abdollahi 0000-0003-0123-1209 Yes Pharmaceutical Sciences Research Center (PSRC), The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran