en Cancer Biology Cancer Biology مقاله کامل Full Length/Original Article <div style="text-align: justify;"><strong>Background:</strong> In recent years, nanotechnology with modern advances in the macromolecular design of&nbsp;nano-carriers has proved to be helpful in the development of drugs delivery systems. This research represents a novel co-administration of nano-vehicles, known as liposomes. Liposomes efficiently encapsulate curcumin and bromocriptine (BR) in a polymer structure, which results in enhanced aqueous solubility of the mentioned hydrophobic agents and higher bioavailability of the drugs. <strong>Methods</strong><strong>:</strong> Preparation of curcumin and BR liposomes were carried out by the thin film method, and the amounts of purified drug and its release were analyzed. After dose determination, the human lung cancer cells (QU-DB) were exposed to BR and curcumin liposomes for 12, 24, and 48 h. Then the viability and apoptosis assays were carried out by using tetrazolium dye and flow cytometry technique, respectively. <strong>Results:</strong> In this research, <em>in vitro</em> anti-cancer effects of former nano-formulations on lung cancer cells was confirmed, and no cytotoxicity effects of these nano-preparations were observed in the normal cells (HFLF-PI5). <strong>Conclusion:</strong> Our findings suggest the nano-liposomal drugs as effective anti-cancer agents; however,&nbsp;additional clinical examinations are required.&nbsp;</div> Apoptosis, Bromocriptine, Curcumin 24 29 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-791&slc_lang=en&sid=1 Mojgan Sheikhpour 0000-0002-1927-6555 Yes Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran Majid Sadeghizadeh 0000-0002-2497-3152 No Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran Fatemeh Yazdian 0000-0002-0550-9821 No Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran Ali Mansoori 0000-0002-0289-455X No Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, Iran Hassan Asadi 0000-0003-3652-3180 No Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran Abolfazl Movafagh 0000-0001-7402-7677 No Department of Medical Genetics, Cancer Research Center, Shohada Hospital School of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran Seyed Sadegh Shahraeini 0000-0002-4854-570X No Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran