Iranian Biomedical Journal
مجله بیومدیکال ایران
IBJ
Basic Sciences
http://ibj.pasteur.ac.ir
1
admin
1028-852X
2008-823X
-
10.61186/ibj
-
8888
-
en
jalali
1398
2
1
gregorian
2019
5
1
23
3
online
1
fulltext
en
Application of Artificial Neural Network in miRNA Biomarker Selection and Precise Diagnosis of Colorectal Cancer
Cancer Biology
Cancer Biology
مقاله کامل
Full Length/Original Article
<strong>Background:</strong> The early diagnosis of colorectal cancer (CRC) is associated with improved survival rates, and development of novel non-invasive, sensitive, and specific diagnostic tests is highly demanded. The objective of this paper was to identify commonly circulating microRNA (miRNA) biomarkers for use in CRC diagnosis. <strong>Methods:</strong> For this purpose, an artificial neural network (ANN) model was proposed. Among miRNAs retrieved from the Gene Expression Omnibus dataset, four miRNAs with the best miRNA score were selected by ANN units. <strong>Results:</strong> The simulation results showed that the designed ANN model could accurately classify the sample data into cancerous or non-cancerous. Furthermore, based on the results of evaluated ANN model, the area under the ROC curve (AUC) of the designed ANN model as well as the regression coefficient between the output of the ANN and the expected output was one. The confusion matrix of the ANN model indicated that all non-cancerous patients were predicted as normal, and the cancerous patients as cancerous. <strong>Conclusion:</strong> Our findings suggest that the improved model can be used as a robust prediction toolbox for cancer diagnosis. In conclusion, by using ANN, circulatory miRNAs can be used as a non-invasive, sensitive and specific diagnostic marker.
Artificial neural network, Biomarkers, Colorectal neoplasms, Diagnosis, MicroRNAs
175
183
http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-743&slc_lang=en&sid=1
Saeid
Afshar
100319475328460054837
100319475328460054837
No
Research Center for Molecular Medicine, Hamadan University of Medical Science, Hamadan, Iran
Research Center for Molecular Medicine, Hamadan University of Medical Science, Hamadan, Iran
Sepideh
Afshar
100319475328460054838
100319475328460054838
No
Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Emily
Warden
100319475328460054839
100319475328460054839
No
Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Hamed
Manochehri
100319475328460054840
100319475328460054840
No
Research Center for Molecular Medicine, Hamadan University of Medical Science, Hamadan, Iran
Massoud
Saidijam
100319475328460054841
100319475328460054841
Yes
Research Center for Molecular Medicine, Hamadan University of Medical Science, Hamadan, Iran