en Enzymology and Protein Chemistry Enzymology and Protein Chemistry مقاله کامل Full Length/Original Article <strong>Background</strong>: Increasing the prevalence of type 2 diabetes has given rise to a global health burden and a concern among health service providers and health administrators. The current study aimed at developing and comparing some statistical models to identify the risk factors associated with type 2 diabetes. In this light, artificial neural network (ANN), support vector machines (SVMs), and multiple logistic regression (MLR) models were applied, using demographic, anthropometric, and biochemical characteristics, on a sample of 9528 individuals from Mashhad City in Iran. <strong>Methods</strong>: This study has randomly selected 6654 (70%) cases for training and reserved the remaining 2874 (30%) cases for testing. The three methods were compared with the help of ROC curve. <strong>Results</strong>: The prevalence rate of type 2 diabetes was 14% in our population. The ANN model had 78.7% accuracy, 63.1% sensitivity, and 81.2% specificity. Also, the values of these three parameters were 76.8%, 64.5%, and 78.9%, for SVM and 77.7%, 60.1%, and 80.5% for MLR. The area under the ROC curve was 0.71 for ANN, 0.73 for SVM, and 0.70 for MLR. <strong>Conclusion</strong>: Our findings showed that ANN performs better than the two models (SVM and MLR) and can be used effectively to identify the associated risk factors of type 2 diabetes. Support vector machine, Data mining, Diabetes type 2 303 311 http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-1-711&slc_lang=en&sid=1 Habibollah Esmaeily 0000-0003-4139-546X Yes Department of Biostatistics, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran Maryam Tayefi 0000-0003-4637-7754 No Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Majid Ghayour-Mobarhan 0000-0002-1081-6754 No Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Alireza Amirabadizadeh 0000-0002-2495-5042 No Medical Toxicology and Drug Abuse Research Center (MTDRC), Birjand University of Medical Sciences, South Khorasan, Iran